ReviewCurrent opinion in genetics & development2008
Eloquent silence: developmental functions of Class I histone deacetylases.
Review in Current opinion in genetics & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 94 citations in OpenAlex.
- Pharmacological inhibition of RE1 silencing transcription factor disrupts SOX2 expression and neurogenesis in human induced pluripotent stem cells derived neuronal models.Metabolic brain disease · 2025Article
- Genetic variations and functions of KLF14 in gene expression and metabolic disease development.Journal of applied genetics · 2025Review
- Krüppel-like factors family in health and disease.MedComm · 2024Review
- Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex.Nature communications · 2023Article
- Biochemical Activation and Regulatory Functions of Trans-Regulatory KLF14 and Its Association with Genetic Polymorphisms.Metabolites · 2023Review
- Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay.Cell genomics · 2023Article
- CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Chromatin-modifying drugs and metabolites in cell fate control.Cell proliferation · 2020Review
- Estrogen receptor α (ERα)-binding super-enhancers drive key mediators that control uterine estrogen responses in mice.The Journal of biological chemistry · 2020Article
- CoRest1 regulates neurogenesis in a stage-dependent manner.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- Article
- Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes.Journal of molecular and cellular cardiology · 2017Article
- Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration.Nature communications · 2017Article
- Solution NMR Studies of an Alternative Mode of Sin3 Engagement by the Sds3 Subunit in the Histone Deacetylase-Associated Sin3L/Rpd3L Corepressor Complex.Journal of molecular biology · 2015Article
- Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs.The American journal of pathology · 2015Article
- Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Non-sirtuin histone deacetylases in the control of cardiac aging.Journal of molecular and cellular cardiology · 2015Review
- Acetyl-lysine erasers and readers in the control of pulmonary hypertension and right ventricular hypertrophy.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2015Review
- Emerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series).Pulmonary circulation · 2015Review
- Alterations in ubiquitin ligase Siah-2 and its corepressor N-CoR after P-MAPA immunotherapy and anti-androgen therapy: new therapeutic opportunities for non-muscle invasive bladder cancer.International journal of clinical and experimental pathology · 2015Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Histone deacetylases (HDACs) are essential catalytic components of the transcription silencing machinery and they play important roles in the programming of multicellular development. HDACs are present within multisubunit protein complexes, other components of which govern HDAC target gene specificity by controlling interactions with sequence-specific DNA-binding proteins. Here, I review the different developmental roles of the Sin3, NuRD, CoREST and NCoR/SMRT Class I HDAC complexes. With their distinct subunit composition, these versatile molecular devices function in many different settings, to promote axis specification and tissue patterning, to maintain stem cell pluripotency, facilitate self-renewal, guide lineage commitment and drive cell differentiation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.