Evidence map›Paper›PMID 18929580›Full record

ReviewMicrovascular research2009

Acute kidney injury and lung dysfunction: a paradigm for remote organ effects of kidney disease?

J D Paladino, J R Hotchkiss, H Rabb

Open access · greenAbstract readReview
In one paragraph

Review in Microvascular research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Protective Role of Octreotide in Acute and Chronic Lung Injuries.International journal of preventive medicine · 2026
    Article
  3. Soft tissue calcifications in chronic kidney disease-beyond the vasculature.Pflugers Archiv : European journal of physiology · 2025
    Review
  4. Article
  5. Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases.American journal of physiology. Lung cellular and molecular physiology · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Norepinephrine released by intestinal Paneth cells exacerbates ischemic AKI.American journal of physiology. Renal physiology · 2020
    Article
  10. Article
  11. Nephrogenic acute respiratory distress syndrome: A narrative review on pathophysiology and treatment.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. αKlotho deficiency in acute kidney injury contributes to lung damage.Journal of applied physiology (Bethesda, Md. : 1985) · 2016
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

J D PaladinoDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
J R Hotchkiss
H Rabb
University of Pittsburgh · USJohns Hopkins University · US

Funding

VENTILATOR ASSOCIATED LUNG INJURY: MOLECULAR APPROACHESP50HL073994 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BROWER, ROY G. · 2003 to 2007
$21.3M
Multidisciplinary Training in Critical Care Outcomes ResearchT32HL007820 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy D Girard, Jeremy M Kahn · 1996 to 2026
$6.4M
NHLBI NIH HHS P50 HL073994NHLBI NIH HHS T32 HL007820
6 · The paper itself

Abstract

An increasing body of evidence suggests that the deleterious effects of Acute Kidney Injury (AKI) on remote organ function could, at least in part, be due to loss of the normal balance of immune, inflammatory, and soluble mediator metabolism that attends injury of the tubular epithelium. Such dysregulation, acting at least in part on endothelium, leads to compromise of remote organ function. Kidney-lung interaction in the setting of AKI therefore constitutes not only a pressing clinical problem, but also an illuminating framework in which to consider possible mechanisms by which renal diseases exert such deleterious effects on patient outcomes, even when dialysis is provided.

Indexed as

Acute Kidney InjuryAcute Lung InjuryAnimalsBrainCapillary PermeabilityHeartHumansKidneyLungNeutrophil Activation

Identifiers

PMID18929580
PMCPMC2679957
OpenAlexW2082218516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.