Evidence map›Paper›PMID 18929160›Full record

ArticleSeminars in perinatology2008

Posttranslational regulation of surfactant protein B expression.

Susan Guttentag

Abstract read
In one paragraph

Article in Seminars in perinatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Genetic disorders of surfactant dysfunction.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Susan GuttentagDepartment of Pediatrics, Division of Neonatology, The University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.
Children's Hospital of Philadelphia · US

Funding

MOLECULAR SIGNALS FOR TRAFFICKING SURFACTANT PROTEIN BR01HL059959 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI GUTTENTAG, SUSAN H. · 1998 to 2011
$3.4M
Molecular Signals for Trafficking Surfactant Protein BR56HL059959 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI GUTTENTAG, SUSAN H. · 2007 to 2007
$378k
NHLBI NIH HHS HL059959NHLBI NIH HHS R01 HL059959NHLBI NIH HHS R56 HL059959
6 · The paper itself

Abstract

Although a minor constituent by weight, surfactant protein B (SP-B) plays a major role in surfactant function. It is the unique structure of SP-B that promotes permeabilization, cross-linking, mixing, and fusion of phospholipids, facilitating the proper structure and function of pulmonary surfactant as well as contributing to the formation of lamellar bodies. SP-B production is a complex process within alveolar type 2 cells and is under hormonal and developmental control. Understanding the posttranslational events in the maturation of SP-B may provide new insight into the process of lamellar body formation and into the pathophysiology of pulmonary disorders associated with surfactant abnormalities.

Indexed as

DimerizationGene Expression RegulationGlycosylationHumansPeptide HydrolasesProtein FoldingProtein PrecursorsProtein Processing, Post-TranslationalProteolipidsPulmonary AlveoliPulmonary Surfactant-Associated Protein BPeptide HydrolasesProtein PrecursorsProteolipidsPulmonary Surfactant-Associated Protein Bsurfactant protein B propeptide

Identifiers

PMID18929160
PMCPMC2586979
OpenAlexW2079334557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.