ArticleBMC genomics2008
Disturbances in metabolic, transport and structural genes in experimental colonic inflammation in the rat: a longitudinal genomic analysis.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Quality of methods reporting in animal models of colitis.Inflammatory bowel diseases · 2015Pooled it
- ToxCompl completion of the DrugMatrix toxicogenomics database: an integrated resource for hypothesis generation.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- miR-146a regulates the crosstalk between intestinal epithelial cells, microbial components and inflammatory stimuli.Scientific reports · 2018Article
- Adenylyl cyclase 6 is involved in the hyposecretory status of experimental colitis.Pflugers Archiv : European journal of physiology · 2018Article
- Calprotectin protects against experimental colonic inflammation in mice.British journal of pharmacology · 2018Article
- Application of Comparative Transcriptional Genomics to Identify Molecular Targets for Pediatric IBD.Frontiers in immunology · 2015Article
- Food derived bioactive peptides and intestinal barrier function.International journal of molecular sciences · 2014Review
- Bioluminescence imaging for IL-1β expression in experimental colitis.Journal of inflammation (London, England) · 2013Article
- Article
- Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- Temporal genome expression profile analysis during t-cell-mediated colitis: identification of novel targets and pathways.Inflammatory bowel diseases · 2012Article
- Proteome profiling of spinal cord and dorsal root ganglia in rats with trinitrobenzene sulfonic acid-induced colitis.World journal of gastroenterology · 2012Article
- Temporal genomewide expression profiling of DSS colitis reveals novel inflammatory and angiogenesis genes similar to ulcerative colitis.Physiological genomics · 2011Article
- Ion channel remodeling in gastrointestinal inflammation.Neurogastroenterology and motility · 2010Review
- GSEA-SNP identifies genes associated with Johne's disease in cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPARalpha.PPAR research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTrinitrobenzenesulphonic acid (TNBS) induced rat colitis is one of the most widely used models of inflammatory bowel disease (IBD), a condition whose aetiology and pathophysiology are incompletely understood. We have characterized this model at the genomic level using a longitudinal approach. Six control rats were compared with colitic animals at 2, 5, 7 and 14 days after TNBS administration (n = 3). The Affymetrix Rat Expression Array 230 2.0 system was used.
resultsTNBS-induced colitis had a profound impact on the gene expression profile, which was maximal 5 and 7 days post-induction. Most genes were affected at more than one time point. They were related to a number of biological functions, not only inflammation/immunity but also transport, metabolism, signal transduction, tissue remodeling and angiogenesis. Gene changes generally correlated with the severity of colitis. The results were successfully validated in a subset of genes by real-time PCR.
conclusionThe TNBS model of rat colitis has been described in detail at the transcriptome level. The changes observed correlate with pathophysiological disturbances such as tissue remodelling and alterations in ion transport, which are characteristic of both this model and IBD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.