ArticlePLoS genetics2008
The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Bio-orthogonal Glycan Imaging of Cultured Cells and Whole AnimalACS central science · 2025Article
- Neurogenesis in Caenorhabditis elegans.Genetics · 2024Review
- A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis.Nature communications · 2024Article
- Article
- Cell-specific effects of the sole C. elegans Daughterless/E protein homolog, HLH-2, on nervous system development.Development (Cambridge, England) · 2023Article
- A spatiotemporal reconstruction of theeLife · 2022Article
- The enteric nervous system of theeLife · 2022Article
- C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation.The Journal of general physiology · 2022Article
- Temporal Regulation of Gene Expression in Post-Mitotic Cells is Revealed from a Synchronized Population ofmicroPublication biology · 2022Article
- RNA-Seq reveals divergent gene expression between larvae with contrasting trophic modes in the poecilogonous polychaete Boccardia wellingtonensis.Scientific reports · 2021Article
- Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors in Caenorhabditis elegans.Development (Cambridge, England) · 2021Article
- Secrets of secretion-How studies of the Drosophila salivary gland have informed our understanding of the cellular networks underlying secretory organ form and function.Current topics in developmental biology · 2021Article
- Review
- Unconventional function of an Achaete-Scute homolog as a terminal selector of nociceptive neuron identity.PLoS biology · 2018Article
- PQN-75 is expressed in the pharyngeal gland cells ofBiology open · 2017Article
- Overlapping cell population expression profiling and regulatory inference in C. elegans.BMC genomics · 2016Article
- The Bicoid class homeodomain factors ceh-36/OTX and unc-30/PITX cooperate in C. elegans embryonic progenitor cells to regulate robust development.PLoS genetics · 2015Article
- TGF-β signaling can act from multiple tissues to regulate C. elegans body size.BMC developmental biology · 2014Article
- The translational regulators GCN-1 and ABCF-3 act together to promote apoptosis in C. elegans.PLoS genetics · 2014Article
- CEH-28 activates dbl-1 expression and TGF-β signaling in the C. elegans M4 neuron.Developmental biology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Caenorhabditis elegans pharynx (or foregut) functions as a pump that draws in food (bacteria) from the environment. While the "organ identity factor" PHA-4 is critical for formation of the C. elegans pharynx as a whole, little is known about the specification of distinct cell types within the pharynx. Here, we use a combination of bioinformatics, molecular biology, and genetics to identify a helix-loop-helix transcription factor (HLH-6) as a critical regulator of pharyngeal gland development. HLH-6 is required for expression of a number of gland-specific genes, acting through a discrete cis-regulatory element named PGM1 (Pharyngeal Gland Motif 1). hlh-6 mutants exhibit a frequent loss of a subset of glands, while the remaining glands have impaired activity, indicating a role for hlh-6 in both gland development and function. Interestingly, hlh-6 mutants are also feeding defective, ascribing a biological function for the glands. Pharyngeal pumping in hlh-6 mutants is normal, but hlh-6 mutants lack expression of a class of mucin-related proteins that are normally secreted by pharyngeal glands and line the pharyngeal cuticle. An interesting possibility is that one function of pharyngeal glands is to secrete a pharyngeal lining that ensures efficient transport of food along the pharyngeal lumen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.