ArticlePLoS pathogens2008
Evidence for restriction of ancient primate gammaretroviruses by APOBEC3 but not TRIM5alpha proteins.
Article in PLoS pathogens, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Riboflavin transporter: evidence of a role as entry receptor for chimpanzee endogenous retrovirus.Virus evolution · 2025Article
- Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity.Molecular biology and evolution · 2018Article
- Reconstruction of a replication-competent ancestral murine endogenous retrovirus-L.Retrovirology · 2018Article
- Review
- Article
- The KT Jeang Retrovirology prize 2015: Paul Bieniasz.Retrovirology · 2015Article
- The decline of human endogenous retroviruses: extinction and survival.Retrovirology · 2015Article
- Evolution of the retroviral restriction gene Fv1: inhibition of non-MLV retroviruses.PLoS pathogens · 2014Article
- Review
- Apparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5αs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Review
- Endogenous retroviruses and multiple sclerosis-new pieces to the puzzle.BMC neurology · 2013Review
- Footprint of APOBEC3 on the genome of human retroelements.Journal of virology · 2013Article
- Article
- Endogenous viruses: insights into viral evolution and impact on host biology.Nature reviews. Genetics · 2012Review
- Role of Human TRIM5α in Intrinsic Immunity.Frontiers in microbiology · 2012Article
- Polymorphisms in the α4 integrin of neotropical primates: insights for binding of natural ligands and HIV-1 gp120 to the human α4β7.PloS one · 2011Article
- Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related lagomorpha TRIM5 genes.Journal of virology · 2010Article
- Identification of a receptor for an extinct virus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Paleovirology--modern consequences of ancient viruses.PLoS biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Because of evolutionary pressures imposed through episodic colonization by retroviruses, many mammals express factors, such as TRIM5alpha and APOBEC3 proteins, that directly restrict retroviral replication. TRIM5 and APOBEC restriction factors are most often studied in the context of modern primate lentiviruses, but it is likely that ancient retroviruses imposed the selective pressure that is evident in primate TRIM5 and APOBEC3 genes. Moreover, these antiretroviral factors have been shown to act against a variety of retroviruses, including gammaretroviruses. Endogenous retroviruses can provide a 'fossil record' of extinct retroviruses and perhaps evidence of ancient TRIM5 and APOBEC3 antiviral activity. Here, we investigate whether TRIM5 and APOBEC3 proteins restricted the replication of two groups of gammaretroviruses that were endogenized in the past few million years. These endogenous retroviruses appear quite widespread in the genomes of old world primates but failed to colonize the human germline. Our analyses suggest that TRIM5alpha proteins did not pose a major barrier to the cross-species transmission of these two families of gammaretroviruses, and did not contribute to their extinction. However, we uncovered extensive evidence for inactivation of ancient gammaretroviruses through the action of APOBEC3 cytidine deaminases. Interestingly, the identities of the cytidine deaminases responsible for inactivation appear to have varied in both a virus and host species-dependent manner. Overall, sequence analyses and reconstitution of ancient retroviruses from remnants that have been preserved in the genomes of modern organisms offer the opportunity to probe and potentially explain the evolutionary history of host defenses against retroviruses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.