ReviewCancer biology & therapy2008
Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase.
Review in Cancer biology & therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Finding novel vulnerabilities of hypomorphic BRCA1 alleles.Molecular oncology · 2026Article
- Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment.Frontiers in immunology · 2025Review
- Centrosomes and associated proteins in pathogenesis and treatment of breast cancer.Frontiers in oncology · 2024Review
- Differential requirement for BRCA1-BARD1 E3 ubiquitin ligase activity in DNA damage repair and meiosis in the Caenorhabditis elegans germ line.PLoS genetics · 2023Article
- RAD6 inhibition enhances paclitaxel sensitivity of triple negative breast cancer cells by aggravating mitotic spindle damage.BMC cancer · 2022Article
- Hereditary breast and ovarian cancer (HBOC): review of its molecular characteristics, screening, treatment, and prognosis.Breast cancer (Tokyo, Japan) · 2021Review
- The BRCA1/BARD1 ubiquitin ligase and its substrates.The Biochemical journal · 2021Review
- Review
- Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors.Cells · 2020Review
- Overcome cancer drug resistance by targeting epigenetic modifications of centrosome.Cancer drug resistance (Alhambra, Calif.) · 2019Review
- The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans.PLoS genetics · 2018Article
- FANCJ at the FORK.Mutation research · 2016Review
- The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability.Oncogene · 2016Article
- CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Centrosomes and cancer: revisiting a long-standing relationship.Nature reviews. Cancer · 2015Review
- Nuclear CSPP1 expression defined subtypes of basal-like breast cancer.British journal of cancer · 2014Article
- DNA-PKcs activates the Chk2-Brca1 pathway during mitosis to ensure chromosomal stability.Oncogenesis · 2014Article
- OLA1 in centrosome biology alongside the BRCA1/BARD1 complex: looking beyond centrosomes.Molecular cell · 2014Article
- Centrosome/Cell cycle uncoupling and elimination in the endoreduplicating intestinal cells of C. elegans.PloS one · 2014Article
- FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.Biology open · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Centrosomes are the organelles that organize microtubule networks and establish the bipolar mitotic spindle, which is essential for the segregation of chromosomes during cell division. Proper duplication of centrosomes is necessary to prevent genetic instability, thus control of this organelle is important in the suppression of tumorigenesis. The BRCA1 dependent ubiquitination activity regulates centrosome number in breast derived cell lines and this activity is likely critical for the tumor suppression activity of BRCA1. This review will focus on the importance of controlling centrosome number and on the effect of BRCA1 on the centrosome duplication cycle in mammary cells.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.