ArticleDevelopment (Cambridge, England)2008
The development of motor coordination in Drosophila embryos.
Article in Development (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 106 citations in OpenAlex.
- Distinct and common dynamics of central brain spontaneous neuronal activity across cell types during Drosophila pupal development.Scientific reports · 2026Article
- REM-sleep twitching in adults and the maintenance of specialized sensorimotor systems.Current biology : CB · 2026Review
- Maturation of GABAergic signalling times the opening of a critical period in Drosophila melanogaster.Scientific reports · 2025Article
- Mitochondrial ROS and HIF-1α signaling mediate synaptic plasticity in the critical period.PLoS biology · 2025Article
- Vertebrates show coordinated elevated expression of mitochondrial and nuclear genes after birth.Genome research · 2025Article
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- OptoChamber: A Low-cost, Easy-to-Make, Customizable, and Multi-Chambered Electronic Device for Applying Optogenetic Stimulation to LarvalmicroPublication biology · 2024Article
- Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo.Nature communications · 2023Article
- A Drosophila glial cell atlas reveals a mismatch between transcriptional and morphological diversity.PLoS biology · 2023Article
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- Critical periods inFrontiers in physiology · 2022Review
- Mechanosensory input during circuit formation shapes Drosophila motor behavior through patterned spontaneous network activity.Current biology : CB · 2021Article
- Nitric oxide mediates activity-dependent change to synaptic excitation during a critical period in Drosophila.Scientific reports · 2021Article
- Pupal behavior emerges from unstructured muscle activity in response to neuromodulation ineLife · 2021Article
- Astrocytes close a motor circuit critical period.Nature · 2021Article
- Review
- TheFrontiers in neural circuits · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We used non-invasive muscle imaging to study the onset of motor activity and emergence of coordinated movement in Drosophila embryos. Earliest movements are myogenic, and neurally controlled muscle contractions first appear with the onset of bursting activity 17 hours after egg laying. Initial episodes of activity are poorly organised and coordinated crawling sequences only begin to appear after a further hour of bursting. Thus, network performance improves during this first period of activity. The embryo continues to exhibit bursts of crawling-like sequences until shortly before hatching, while other reflexes also mature. Bursting does not begin as a reflex response to sensory input but appears to reflect the onset of spontaneous activity in the motor network. It does not require GABA-mediated transmission, and, by using a light-activated channel to excite the network, we demonstrate activity-dependent depression that may cause burst termination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.