ArticleNucleic acids research2009
SDR: a database of predicted specificity-determining residues in proteins.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Recognition of sites of functional specialisation in all known eukaryotic protein kinase families.PLoS computational biology · 2018Article
- The directed evolution of ligand specificity in a GPCR and the unequal contributions of efficacy and affinity.Scientific reports · 2017Article
- Article
- Cube-DB: detection of functional divergence in human protein families.Nucleic acids research · 2012Article
- Collective dynamics differentiates functional divergence in protein evolution.PLoS computational biology · 2012Article
- Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.PLoS genetics · 2011Article
- Identification of family-determining residues in PHD fingers.Nucleic acids research · 2011Article
- Analyzing protein structure and function using ancestral gene reconstruction.Current opinion in structural biology · 2010Review
- Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The specificity-determining residue database (SDR database) presents residue positions where mutations are predicted to have changed protein function in large protein families. Because the database pre-calculates predictions on existing protein sequence alignments, users can quickly find the predictions by selecting the appropriate protein family or searching by protein sequence. Predictions can be used to guide mutagenesis or to gain a better understanding of specificity changes in a protein family. The database is available on the web at http://paradox.harvard.edu/sdr.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.