ArticleThe Journal of biological chemistry2008
Ryanodine receptor activation by Ca v 1.2 is involved in dendritic cell major histocompatibility complex class II surface expression.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Cryo-EM Brings the Mechanisms of Activation, Inactivation, and Inhibition of Ryanodine Receptors into Focus.Advances in experimental medicine and biology · 2026Review
- Review
- Modulation of Adaptive Immunity and Viral Infections by Ion Channels.Frontiers in physiology · 2021Review
- Article
- Calling in the CaFrontiers in cellular and infection microbiology · 2019Review
- Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii.PLoS pathogens · 2017Article
- The role of STIM and ORAI proteins in phagocytic immune cells.American journal of physiology. Cell physiology · 2016Review
- Signature Channels of Excitability no More: L-Type Channels in Immune Cells.Frontiers in immunology · 2015Review
- Divalent cation signaling in immune cells.Trends in immunology · 2014Review
- Targeting ion channels for the treatment of autoimmune neuroinflammation.Therapeutic advances in neurological disorders · 2013Article
- Gain of function in the immune system caused by a ryanodine receptor 1 mutation.Journal of cell science · 2013Article
- Exposure to triclosan augments the allergic response to ovalbumin in a mouse model of asthma.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Emerging roles of L-type voltage-gated and other calcium channels in T lymphocytes.Frontiers in immunology · 2013Review
- Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice.Nature communications · 2013Article
- Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.The Journal of biological chemistry · 2012Article
- The landscape of human genes involved in the immune response to parasitic worms.BMC evolutionary biology · 2010Article
- Frequent calcium oscillations lead to NFAT activation in human immature dendritic cells.The Journal of biological chemistry · 2010Article
- The functional network of ion channels in T lymphocytes.Immunological reviews · 2009Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells express the skeletal muscle ryanodine receptor (RyR1), yet little is known concerning its physiological role and activation mechanism. Here we show that dendritic cells also express the Ca(v)1.2 subunit of the L-type Ca(2+) channel and that release of intracellular Ca(2+) via RyR1 depends on the presence of extracellular Ca(2+) and is sensitive to ryanodine and nifedipine. Interestingly, RyR1 activation causes a very rapid increase in expression of major histocompatibility complex II molecules on the surface of dendritic cells, an effect that is also observed upon incubation of mouse BM12 dendritic cells with transgenic T cells whose T cell receptor is specific for the I-A(bm12) protein. Based on the present results, we suggest that activation of the RyR1 signaling cascade may be important in the early stages of infection, providing the immune system with a rapid mechanism to initiate an early response, facilitating the presentation of antigens to T cells by dendritic cells before their full maturation.
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