ArticleNeuroscience2008
Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons.
Article in Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- The Role of the Immunoglobulin Superfamily of Cell Adhesion Molecules in Intellectual Disability.Cells · 2026Review
- White matter abnormalities in fetal alcohol spectrum disorders: Focus on axon growth and guidance.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Effects of Ethanol on Cellular Composition and Network Excitability of Human Pluripotent Stem Cell-Derived Neurons.Alcoholism, clinical and experimental research · 2016Article
- Quantitative investigations of axonal and dendritic arbors: development, structure, function, and pathology.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2015Review
- Prenatal ethanol exposure disrupts intraneocortical circuitry, cortical gene expression, and behavior in a mouse model of FASD.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- L1 cell adhesion molecule signaling is inhibited by ethanol in vivo.Alcoholism, clinical and experimental research · 2013Article
- Ethanol disrupts axon outgrowth stimulated by netrin-1, GDNF, and L1 by blocking their convergent activation of Src family kinase signaling.Journal of neurochemistry · 2012Article
- Cyanidin-3-glucoside ameliorates ethanol neurotoxicity in the developing brain.Journal of neuroscience research · 2011Article
- Ethanol induces endoplasmic reticulum stress in the developing brain.Alcoholism, clinical and experimental research · 2011Article
- L1 cell adhesion molecule promotes resistance to alcohol-induced silencing of growth cone responses to guidance cues.Neuroscience · 2011Article
- Article
- L1CAM malfunction in the nervous system and human carcinomas.Cellular and molecular life sciences : CMLS · 2010Review
- Ethanol and cognition: indirect effects, neurotoxicity and neuroprotection: a review.International journal of environmental research and public health · 2010Review
- Ethanol inhibits muscarinic receptor-induced axonal growth in rat hippocampal neurons.Alcoholism, clinical and experimental research · 2009Article
- GSK3beta in ethanol neurotoxicity.Molecular neurobiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Humans exposed prenatally to ethanol can exhibit brain abnormalities and cognitive impairment similar to those seen in patients expressing mutant forms of the L1 cell adhesion molecule (L1CAM). The resemblance suggests that L1CAM may be a target for ethanol, and consistent with this idea, ethanol can inhibit L1CAM adhesion in cell lines and L1CAM-mediated outgrowth and signaling in cerebellar granule neurons. However, it is not known whether ethanol inhibits L1CAM function in other neuron types known to require L1CAM for appropriate development. Here we asked whether ethanol alters L1CAM function in neurons of the rat cerebral cortex. We find that ethanol does not alter axonal polarization, L1CAM-dependent axon outgrowth or branching, or L1CAM recycling in axonal growth cones. Thus, ethanol inhibition of L1CAM is highly dependent on neuronal context.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.