ArticleOral surgery, oral medicine, oral pathology, oral radiology, and endodontics2009
Expression analysis of matrix metalloproteinase-9 in epithelialized and nonepithelialized apical periodontitis lesions.
Article in Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Effectiveness of calcium hydroxide-based intracanal medication on infectious/inflammatory contents in teeth with post-treatment apical periodontitis.Clinical oral investigations · 2019Trial
- Effect of intracanal medicaments on matrix metalloproteinase-9 and vasoactive intestinal peptide secretion in periapical lesions of re-treated canals: a randomized controlled clinical study.Clinical oral investigations · 2019Trial
- Cross-Sectional Analysis of Matrix Metalloproteinases and Bone Resorption Regulators in Apical Periodontitis: Linking Molecular Mechanisms with Clinical and Histopathological Features.Acta stomatologica Croatica · 2025Article
- Proteins Associated with Persistent Apical Periodontitis: A Scoping Review.Iranian endodontic journal · 2024Article
- The Link between Periodontal Disease and Asthma: How Do These Two Diseases Affect Each Other?Journal of clinical medicine · 2023Review
- Network pharmacology combined with GEO database identifying the mechanisms and molecular targets of Polygoni Cuspidati Rhizoma on Peri-implants.Scientific reports · 2022Article
- Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment.BMC oral health · 2021Article
- Osteoclast formation, inflammation, and matrix metalloproteinase-9 are downregulated in bone repair following root canal treatment in dogs teeth.Clinical oral investigations · 2021Article
- MMP9 protects against LPS-induced inflammation in osteoblasts.Innate immunity · 2020Article
- Significance of circulating and crevicular matrix metalloproteinase-9 in rheumatoid arthritis-chronic periodontitis association.Journal of immunology research · 2015Article
- Genetic susceptibility to periapical disease: conditional contribution of MMP2 and MMP3 genes to the development of periapical lesions and healing response.Journal of endodontics · 2012Article
- Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response.Journal of inflammation (London, England) · 2012Article
- The effect of raloxifene, a SERM, on extracellular matrix protein expression of pelvic fibroblasts.International urogynecology journal · 2012Article
- Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts.Journal of applied oral science : revista FOB · 2010Article
- Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment.Journal of endodontics · 2010Article
- Retrograde peri-implantitis.Journal of Indian Society of Periodontology · 2010Article
- High matrix metalloproteinase activity is a hallmark of periapical granulomas.Journal of endodontics · 2009Article
- MMP1-1607 polymorphism increases the risk for periapical lesion development through the upregulation MMP-1 expression in association with pro-inflammatory milieu elements.Journal of applied oral science : revista FOBArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe objective of this study was to determine the expression of matrix metalloproteinase-9 (MMP-9) in apical periodontitis lesions. STUDY
designNineteen epithelialized and 18 nonepithelialized apical periodontitis lesions were collected after periapical surgery. After histological processing, serial sectioning, H&E staining, and microscopic analysis, 10 epithelialized and 10 nonepithelialized lesions were selected for immunohistochemical analysis for MMP-9 and CD 68. At least one third of each specimen collected was frozen at -70 degrees C for further mRNA isolation and reverse transcription into cDNA for real-time-PCR procedures. Geometric averaging of multiple housekeeping genes normalized MMP-9 mRNA expression level.
resultsPolymorphonuclear neutrophils, macrophages and lymphocytes presented MMP-9 positive immunostaining in both types of lesions. When present, epithelial cells were also stained. The number and the ratio of MMP-9(+)/total cells were greater in nonepithelialized than epithelialized lesions (P = .0001) presenting a positive correlation to CD68(+)/total cells (P = .045). Both types of lesions presented increased MMP-9 expression (P < .0001) when compared to healthy periapical ligaments. However, no significant differences were observed for MMP-9 mRNA expression between ephithelized and nonephithelized lesions.
conclusionThe present data suggest the participation of several inflammatory cells, mainly CD68(+) cells, in the MMP-9 expression in apical periodontitis lesions. MMP-9 could be actively enrolled in the extracellular matrix degradation in apical periodontitis lesions.
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