ArticleBioorganic & medicinal chemistry letters2008
RNA bandages for photoregulating in vitro protein synthesis.
Article in Bioorganic & medicinal chemistry letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- PhotocleavableChemical reviews · 2023Review
- Expanding Catch and Release DNA Decoy (CRDD) Technology with Pyrimidine Mimics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Deactivatable Bisubstrate Inhibitors of Protein Kinases.Molecules (Basel, Switzerland) · 2022Article
- Translational control of gene function through optically regulated nucleic acids.Chemical Society reviews · 2021Review
- Photoactivatable Circular Caged Oligonucleotides for TranscriptomeChemPhotoChem · 2021Article
- Conditionally Activated ("Caged") Oligonucleotides.Molecules (Basel, Switzerland) · 2021Review
- Optochemical Control of Biological Processes in Cells and Animals.Angewandte Chemie (International ed. in English) · 2018Review
- Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing.Beilstein journal of organic chemistry · 2018Review
- Caged oligonucleotides for studying biological systems.Journal of inorganic biochemistry · 2015Review
- Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue.Nature methods · 2014Article
- Optochemical control of deoxyoligonucleotide function via a nucleobase-caging approach.Accounts of chemical research · 2014Article
- Caged oligonucleotides for bidirectional photomodulation of let-7 miRNA in zebrafish embryos.Bioorganic & medicinal chemistry · 2013Article
- Caged circular antisense oligonucleotides for photomodulation of RNA digestion and gene expression in cells.Nucleic acids research · 2013Article
- Manipulation of gene expression in zebrafish using caged circular morpholino oligomers.Nucleic acids research · 2012Article
- Photomodulating RNA cleavage using photolabile circular antisense oligodeoxynucleotides.Nucleic acids research · 2010Article
- Activation and deactivation of DNAzyme and antisense function with light for the photochemical regulation of gene expression in mammalian cells.Journal of the American Chemical Society · 2010Article
- Principles and applications of the photochemical control of cellular processes.Chembiochem : a European journal of chemical biology · 2010Article
- Light activation as a method of regulating and studying gene expression.Current opinion in chemical biology · 2009Review
- Versatile synthesis and rational design of caged morpholinos.Journal of the American Chemical Society · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
'RNA bandages' are composed of two 6-12-mer 2'-OMe RNA strands complementary to a mRNA target that are joined by a photocleavable linker. These tandem oligonucleotides typically exhibit much higher affinity for the mRNA than the individual strands. An RNA bandage with binding arms of different lengths and a 4-base gap blocked translation in vitro of GFP mRNA; subsequent near-UV irradiation restored translation. This provides a general method of photomodulating hybridization for a variety of oligonucleotide-based technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.