Evidence map›Paper›PMID 18925905›Full record

SynthesisAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2008

Chronic kidney disease after hematopoietic cell transplantation: a systematic review.

M J Ellis, C R Parikh, J K Inrig, M Kanbay, M Kambay, U D Patel

Erratum issuedOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Estimated versus measured glomerular filtration rate in children before hematopoietic cell transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2014
    Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Treatment with Foscarnet after Allogeneic Hematopoietic Cell Transplant (Allo-HCT) Is Associated with Long-Term Loss of Renal Function.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Article
  17. Observational
  18. Article
  19. Acute Kidney Injury in Children after Hematopoietic Cell Transplantation Is Associated with Elevated Urine CXCL10 and CXCL9.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Observational
  20. CKD: A Call for an Age-Adapted Definition.Journal of the American Society of Nephrology : JASN · 2019
    Review
4 · The record

Corrections and comments

  • Erratum issued
    Kambay, M [corrected to Kanbay, M]
5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

M J EllisDivision of Nephrology, Duke University Medical Center, Durham, NC, USA. mattellis8989@mac.com
C R Parikh
J K Inrig
M Kanbay
M Kambay
U D Patel
Duke Medical Center · USYale University · USDuke University Hospital · US

Funding

Barriers to Optimal Cardiovascular Medication Use in Diabetes and Renal DiseaseK23DK075929 · NIDDK · DUKE UNIVERSITY · PI PATEL, UPTAL D · 2006 to 2010
$677k
Renal Failure in Non-Myeloablative Stem Cell TransplantK23DK064689 · NIDDK · YALE UNIVERSITY · PI PARIKH, CHIRAG R · 2003 to 2007
$654k
NCRR NIH HHS KL2RR024123NIDDK NIH HHS K23 DK064689NIDDK NIH HHS K23 DK075929
6 · The paper itself

Abstract

Advances in hematopoietic cell transplantation (HCT) have broadened its indications for use and resulted in more long-term HCT survivors. Some survivors develop chronic kidney disease (CKD); however, the incidence and risk factors are unclear. We performed a systematic review of studies identified from databases (MEDLINE, EMBASE, Science Citation Index), conference abstracts and reference lists from selected manuscripts. From 927 manuscripts, 28 patient cohorts were identified in which 9317 adults and children underwent HCT and 7317 (79%) survived to at least 100 days, permitting inclusion of 5337 (73% of survivors) in quantitative analyses. Although definitions and measurements varied widely, approximately 16.6% of HCT patients developed CKD and estimated glomerular filtration rate (eGFR in mL/min/1.73 m(2)) decreased by 24.5 after 24 months. This decrease was greater amongst patients undergoing allogeneic HCT (DeltaeGFR = -40.0 versus -18.6 for autologous transplants). Several commonly reported risk factors for CKD were investigated, including acute renal failure, total body irradiation, graft versus host disease and long-term cyclosporine use. In conclusion, CKD following HCT is likely to be common; however, prospective studies with uniform definitions of CKD and risk factors are needed to confirm these findings and better define the underlying mechanisms to promote therapies that prevent this complication.

Indexed as

Cohort StudiesCyclosporineGlomerular Filtration RateGraft RejectionHematopoietic Stem Cell TransplantationHumansKidney Failure, ChronicKidney TransplantationOdds RatioRisk FactorsTime FactorsTransplantation, HomologousTreatment OutcomeCyclosporine

Identifiers

PMID18925905
PMCPMC3564956
OpenAlexW1986098263

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.