ArticleArtificial cells, blood substitutes, and immobilization biotechnology2008
Encapsulation of human islets in novel inhomogeneous alginate-ca2+/ba2+ microbeads: in vitro and in vivo function.
Article in Artificial cells, blood substitutes, and immobilization biotechnology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient.Diabetologia · 2013Trial
- Alginate-Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In Vivo.Biomedicines · 2024Article
- Article
- Anti-Inflammatory Effects of Encapsulated Human Mesenchymal Stromal/Stem Cells and a Method to Scale-Up Cell Encapsulation.Biomolecules · 2022Article
- Review
- Coaxial Alginate Hydrogels: From Self-Assembled 3D Cellular Constructs to Long-Term Storage.International journal of molecular sciences · 2021Article
- Microencapsulation of cells and molecular therapy of type 1 diabetes mellitus: The actual state and future perspectives between promise and progress.Journal of diabetes investigation · 2021Review
- In vitro platform establishes antigen-specific CD8Biomaterials · 2020Article
- Dual Crosslinking of Alginate Outer Layer Increases Stability of Encapsulation System.Frontiers in chemistry · 2020Article
- Microencapsulation of cellular aggregates composed of differentiated insulin and glucagon-producing cells from human mesenchymal stem cells derived from adipose tissue.Diabetology & metabolic syndrome · 2020Article
- Characterization of Polyethylene Glycol-Reinforced Alginate Microcapsules for Mechanically Stable Cell Immunoisolation.Macromolecular materials and engineering · 2019Article
- Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques.Nature biomedical engineering · 2018Article
- Sustained exenatide delivery via intracapsular microspheres for improved survival and function of microencapsulated porcine islets.Drug delivery and translational research · 2018Article
- Structural changes in alginate-based microspheres exposed to in vivo environment as revealed by confocal Raman microscopy.Scientific reports · 2018Article
- Synthesis and evaluation of dual crosslinked alginate microbeads.Acta biomaterialia · 2018Article
- Single cell-laden protease-sensitive microniches for long-term culture in 3D.Lab on a chip · 2017Article
- Encapsulated Islet Transplantation: Where Do We Stand?The review of diabetic studies : RDS · 2017Review
- Insight into microenvironment remodeling in pancreatic endocrine tissue engineering: Biological and biomaterial approaches.Tissue engineering and regenerative medicine · 2016Review
- Clinical applications of naturally derived biopolymer-based scaffolds for regenerative medicine.Annals of biomedical engineering · 2015Review
- Immunological and technical considerations in application of alginate-based microencapsulation systems.Frontiers in bioengineering and biotechnology · 2014Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Microencapsulation may allow for immunosuppression-free islet transplantation. Herein we investigated whether human islets can be shipped safely to a remote encapsulation core facility and maintain in vitro and in vivo functionality. In non-encapsulated islets before and encapsulated islets after shipment, viability was 88.3+/-2.5 and 87.5+/-2.7% (n=6, p=0.30). Stimulation index after static glucose incubation was 5.4+/-0.5 and 6.3+/-0.4 (n=6, p=0.18), respectively. After intraperitoneal transplantation, long-term normoglycemia was consistently achieved with 3,000, 5,000, and 10,000 IEQ encapsulated human islets. When transplanting 1,000 IEQ, mice returned to hyperglycemia after 30-55 (n=4/7) and 160 days (n=3/7). Transplanted mice showed human oral glucose tolerance with lower glucose levels than non-diabetic control mice. Capsules retrieved after transplantation were intact, with only minimal overgrowth. This study shows that human islets maintained the viability and in vitro function after encapsulation and the inhomogeneous alginate-Ca(2+)/Ba(2+) microbeads allow for long-term in vivo human islet graft function, despite long-distance shipment.
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Registered trials
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