Trial reportJournal of assisted reproduction and genetics
Recombinant HCG for triggering ovulation increases the rate of mature oocytes in women treated for ICSI.
Trial report in Journal of assisted reproduction and genetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles.The Cochrane database of systematic reviews · 2016Pooled it
- Luteal phase support for assisted reproduction cycles.The Cochrane database of systematic reviews · 2015Pooled it
- Pharmacokinetics of human chorionic gonadotropin injection in obese and normal-weight women.The Journal of clinical endocrinology and metabolism · 2014Trial
- Comparing the efficacy of urinary and recombinant hCG on oocyte/follicle ratio to trigger ovulation in women undergoing intracytoplasmic sperm injection cycles: a randomized controlled trial.Journal of assisted reproduction and genetics · 2013Trial
- Effects of synthetized porcine follicle-stimulating hormone and synthetized human chorionic gonadotropin on reproductive efficiency in pigs.Porcine health management · 2025Article
- Research Progress on the Impact of Human Chorionic Gonadotropin on Reproductive Performance in Sows.Animals : an open access journal from MDPI · 2024Review
- Analytical Investigation of the Profile of Human Chorionic Gonadotropin in Highly Purified Human Menopausal Gonadotrophin Preparations.International journal of molecular sciences · 2024Article
- The optimal period for oocyte retrieval after the administration of recombinant human chorionic gonadotropin in in vitro fertilization.BMC pregnancy and childbirth · 2022Article
- Evaluation of the safety and efficacy of corifollitropin alfa combined with GnRH agonist triggering in oocyte donation cycles. A prospective longitudinal study.JBRA assisted reproduction · 2020Article
- Performing ICSI within 4 hours after denudation optimizes clinical outcomes in ICSI cycles.Reproductive biology and endocrinology : RB&E · 2020Article
- The efficacy of recombinant versus urinary HCG in ART outcome.Iranian journal of reproductive medicine · 2012Article
- Recombinant or urinary human chorionic gonadotropin in ovulation induction?Journal of obstetrics and gynaecology of India · 2011Article
- Pregnancy rates with recombinant versus urinary human chorionic gonadotropin in in vitro fertilization: an observational study.TheScientificWorldJournal · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo conduct a prospective randomized study in order to investigate the effect of recombinant HCG (rHCG) on oocyte nuclear and cytoplasm maturity compared to urinary HCG (uHCG), for inducing ovulation in women treated with ICSI for male factor infertility. MATERIALS AND
methodsWe compared 89 patients randomly assigned to one of the two study groups. Group A consisted of 42 women who received a subcutaneous (s.c.) injection of 250 microg rHCG and group B consisted of 47 patients receiving an intramuscular (i.m.) injection of 10,000 IU uHCG.
resultsPatients treated with rHCG showed a rate of metaphase II oocytes, a number of metaphase II oocytes with mature cytoplasm and a rate of metaphase II oocytes with mature cytoplasm calculated from total MII oocytes statistically higher than in patients treated with uHCG. However this differences were not associated with a significantly better clinical outcome.
conclusionOur data show that in women treated with ICSI for male factor infertility, rHCG increases the rate of metaphase II oocytes, the number and the rate of MII oocytes with mature cytoplasm compared to uHCG. A larger study comparing transfer cycles of embryos all derived from oocytes with mature cytoplasm and transfer cycles of embryos all derived from oocytes with immature cytoplasm may be needed to clarify clinical correlations.
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Registered trials
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