ArticleClinics (Sao Paulo, Brazil)2008
Hip fracture risk and different gene polymorphisms in the Turkish population.
Article in Clinics (Sao Paulo, Brazil), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Association of IL-6 174G/C (rs1800795) and 572C/G (rs1800796) polymorphisms with risk of osteoporosis: a meta-analysis.BMC musculoskeletal disorders · 2020Pooled it
- Pooled it
- Association of vitamin D receptor BsmI gene polymorphism with risk of osteoporosis: a meta-analysis of 41 studies.Molecular biology reports · 2013Pooled it
- Association betweenFrontiers in genetics · 2022Article
- Evaluation of Tryptophan/Kynurenine Pathway Relevance With Immune System Biomarkers of Low Energy Trauma Hip Fractures in Osteoporotic Patients.Archives of rheumatology · 2017Article
- The association between interleukin 6 -174 G/C gene polymorphism and the risk of osteoporosis: A meta-analysis.Journal of Taibah University Medical Sciences · 2017Article
- Estrogen receptor α (ESR1) IVS1-397T>C polymorphism lowers risk of fracture.International journal of clinical and experimental medicine · 2015Article
- Effect of interleukin-6 polymorphism on fracture risk.International journal of clinical and experimental medicine · 2015Article
- Association of collagen type I alpha 1 gene polymorphism with inguinal hernia.Hernia : the journal of hernias and abdominal wall surgery · 2014Article
- IL6-174G/C polymorphism and fracture risk.International journal of clinical and experimental medicine · 2014Article
- Frequencies of interleukin-6, GST and progesterone receptor gene polymorphisms in postmenopausal women with low bone mineral density.Sao Paulo medical journal = Revista paulista de medicina · 2014Article
- Evaluation of ERα and VDR gene polymorphisms in relation to bone mineral density in Turkish postmenopausal women.Molecular biology reports · 2012Article
- Molecular genetic studies of gene identification for osteoporosis: the 2009 update.Endocrine reviews · 2010Review
- Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians.Calcified tissue international · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to discuss the risk assessments for both patients with hip fractures due to fall-related, low energy traumas and non-fractured control patients by examining bone mineral density and genetic data, two features associated with femoral strength and hip fracture risk.
methodsTwenty-one osteoporotic patients with proximal femur fractures and non-fractured, osteoporotic, age- and gender-matched controls were included in the study. Bone mineral density measurements were performed with a Lunar DXA. The COL1A1, ESR, VDR, IL-6, and OPG genes were amplified, and labeling of specific gene sequences was performed in a multiplex polymerase chain reaction using the osteo/check PCR kit from the whole blood of all subjects.
resultsThe bone mineral density (trochanteric and total bone mineral density values) of the fracture group was significantly decreased relative to the control group. We were not able to conduct statistical tests for the polymorphisms of the COL1A1, ESR, and VDR genes because our results were expressed in terms of frequency. Although they were not significant, we did examine differences in the IL-6 and OPG genes polymorphisms between the two groups. We concluded that increasing the number of cases will allow us to evaluate racial differences in femoral hip fracture risk by genotypes.
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