ArticleClinics (Sao Paulo, Brazil)2008
Malignant and tuberculous pleural effusions: immunophenotypic cellular characterization.
Article in Clinics (Sao Paulo, Brazil), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- A meta-analysis of Th1 and Th2 cytokine profiles differentiating tuberculous from malignant pleural effusion.Scientific reports · 2022Pooled it
- Immunodynamic changes in a mouse model of malignant pleural effusion.Laboratory animal research · 2026Article
- Efferocytosis fuels malignant pleural effusion through TIMP1.Science advances · 2021Article
- Higher CD4/CD8 ratio of pleural effusion predicts better survival for lung cancer patients receiving immune checkpoint inhibitors.Scientific reports · 2021Article
- Migrated T lymphocytes into malignant pleural effusions: an indicator of good prognosis in lung adenocarcinoma patients.Scientific reports · 2019Article
- Secretion of IFN-γ Associated with Galectin-9 Production by Pleural Fluid Cells from a Patient with Extrapulmonary Tuberculosis.International journal of molecular sciences · 2017Article
- Down-regulation of miR-20a-5p triggers cell apoptosis to facilitate mycobacterial clearance through targeting JNK2 in human macrophages.Cell cycle (Georgetown, Tex.) · 2016Article
- Analysis of Lymphocyte Immunological Reactivity in Patients with Pleural Effusions of Different Aetiology.Open access Macedonian journal of medical sciences · 2016Article
- Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion.International journal of general medicine · 2016Article
- Pleural sarcoidosis diagnosed on the basis of an increased CD4/CD8 lymphocyte ratio in pleural effusion fluid: a case report.Journal of medical case reports · 2015Article
- The CD4+/CD8+ Ratio in Pulmonary Tuberculosis: Systematic and Meta-Analysis Article.Iranian journal of public health · 2015Review
- Defect in recruiting effector memory CD8+ T-cells in malignant pleural effusions compared to normal pleural fluid.BMC cancer · 2013Article
- Transient expansion of activated CD8(+) T cells characterizes tuberculosis-associated immune reconstitution inflammatory syndrome in patients with HIV: a case control study.Journal of inflammation (London, England) · 2013Article
- Polyfunctional Mycobacterium tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB.Tuberculosis (Edinburgh, Scotland) · 2011Article
- Does the evaluation of coagulation factors contribute to etiological diagnosis of pleural effusions?Clinics (Sao Paulo, Brazil) · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
INTRODUCTION AND
objectivesTuberculosis and cancer are the main causes of pleural effusion. Pleural involvement is associated with migration of immune cells to the pleural cavity. We sought to characterize the immunophenotype of leukocytes in the pleural effusion and peripheral blood of patients with tuberculosis or malignancy.
methodsThirty patients with tuberculosis (14) or malignancy (16) were studied. A control group included 20 healthy blood donors.
resultsMalignant phycoerythrin pleural effusions showed higher percentages of CD3, CD4, CD3CD45RO, and CD20CD25 lymphocytes and lower percentages of CD3CD25 and CD20HLA-DR when compared to PB lymphocytes. Compared to PB, tuberculous effusions had a higher percentage of lymphocytes that co-expressed CD3, CD4, CD3CD45RO, CD3TCRalphabeta, CD3CD28, and CD20 and a lower percentage of CD14, CD8 and CD3TCRgammadelta-positive lymphocytes. Malignant effusions presented higher expression of CD14 whereas tuberculous effusions had higher expression of CD3 and CD3CD95L. Peripheral blood cells from tuberculosis patients showed higher expression of CD14, CD20CD25 and CD3CD95L. Compared with the control cells, tuberculosis and cancer peripheral blood cells presented a lower percentage of CD3CD4 and CD3CD28-positive cells as well as a higher percentage of CD3CD8, CD3CD25 and CD3CD80-positive cells.
conclusionsTuberculous and malignant peripheral blood is enriched with lymphocytes with a helper/inducer T cell phenotype, which are mainly of memory cells. CD14-positive cells were more frequently found in malignant effusions, while CD3-positive cells expressing Fas ligand were more frequently found in tuberculous effusions.
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