ArticleCanadian journal of gastroenterology = Journal canadien de gastroenterologie2008
Autoimmune hepatitis in a North American Aboriginal/First Nations population.
Article in Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- The Geoepidemiology of Autoimmune Hepatitis.Clinical reviews in allergy & immunology · 2026Review
- Autoimmune Hepatitis: A Diagnostic and Therapeutic Overview.Diagnostics (Basel, Switzerland) · 2024Review
- Autoimmune hepatitis presenting with concomitant chronic pancreatitis.Radiology case reports · 2023Article
- Post-transplant diabetes mellitus in Canadian liver and renal transplant recipients.Canadian liver journal · 2022Article
- Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans.The American journal of gastroenterology · 2018Article
- Similarities and Differences in Autoimmune Hepatitis Epidemiology between East and West: Autoimmune Hepatitis in East Asia, Southeast Asia, and South Asia.Inflammatory intestinal diseases · 2017Review
- Nonalcoholic Fatty Liver Disease in Canadian First Nations and Non-First Nations Patients.Canadian journal of gastroenterology & hepatology · 2016Article
- Hepatitis C virus in American Indian/Alaskan Native and Aboriginal peoples of North America.Viruses · 2012Review
- Advances in the current treatment of autoimmune hepatitis.Digestive diseases and sciences · 2012Review
- Liver transplant outcomes in a Canadian First Nations population.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2011Article
- Lessons learned from liver transplantation with the Canadian First Nations.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2011Article
- Complement mediated hepatocytes injury in a model of autoantibody induced hepatitis.Immunobiology · 2011Article
- Non-classical phenotypes of autoimmune hepatitis and advances in diagnosis and treatment.World journal of gastroenterology · 2009Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
North American Aboriginal populations are at increased risk for developing immune-mediated disorders, including autoimmune hepatitis. In the present study, the demographic, clinical, biochemical, serological, radiological and histological features of autoimmune hepatitis were compared in 33 First Nations (FN) and 150 predominantly Caucasian, non-FN patients referred to an urban tertiary care centre. FN patients were more often female (91% versus 71%; P=0.04), and more likely to have low serum albumin (69% versus 36%; P=0.0006) and elevated bilirubin (57% versus 35%; P=0.01) levels on presentation compared with non-FN patients. They also had lower hemoglobin, and complement levels, more cholestasis and higher serum immunoglobulin A levels than non-FN patients (P=0.05 respectively). Higher histological grades of inflammation and stages of fibrosis, and more clinical and radiological evidence of advanced liver disease were observed in FN patients, but the differences failed to reach statistical significance. The results of the present study suggest that in addition to being more common, autoimmune hepatitis may be more severe in FN populations, compared with predominantly Caucasian, non-FN populations.
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Registered trials
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