ArticleCerebellum (London, England)2008
The role of thyroid hormone on cerebellar development.
Article in Cerebellum (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Review
- Involvement of integrin αvβ3 in thyroid hormone-induced dendritogenesis.Frontiers in endocrinology · 2022Article
- The Role of Ferrous Ion in the Effect of the Gadolinium-Based Contrast Agents (GBCA) on the Purkinje Cells Arborization: An In Vitro Study.Diagnostics (Basel, Switzerland) · 2021Article
- Change of pace: How developmental tempo varies to accommodate failed provision of early needs.Neuroscience and biobehavioral reviews · 2021Review
- Absence of Thyroid Hormone Induced Delayed Dendritic Arborization in Mouse Primary Hippocampal Neurons Through Insufficient Expression of Brain-Derived Neurotrophic Factor.Frontiers in endocrinology · 2021Article
- Urinary Concentrations of Phthalate Metabolite Mixtures in Relation to Serum Biomarkers of Thyroid Function and Autoimmunity among Women from a Fertility Center.Environmental health perspectives · 2020Article
- Associations Between Maternal Thyroid Function in Pregnancy and Obstetric and Perinatal Outcomes.The Journal of clinical endocrinology and metabolism · 2020Article
- MicroRNA-1236-3p/translationally controlled tumor protein (TPT1) axis participates in congenital hypothyroidism progression by regulating neuronal apoptosis.Experimental and therapeutic medicine · 2020Article
- A Novel Mechanism of S-equol Action in Neurons and Astrocytes: The Possible Involvement of GPR30/GPER1.International journal of molecular sciences · 2019Article
- Critical Period Regulation by Thyroid Hormones: Potential Mechanisms and Sex-Specific Aspects.Frontiers in molecular neuroscience · 2019Article
- Central Hypothyroidism and Novel Clinical Phenotypes in Hemizygous Truncation ofJournal of the Endocrine Society · 2019Article
- The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats.Metabolic brain disease · 2018Article
- The Effects of Gadolinium-Based Contrast Agents on the Cerebellum: from Basic Research to Neurological Practice and from Pregnancy to Adulthood.Cerebellum (London, England) · 2018Article
- Brain and Hepatic Mt mRNA Is Reduced in Response to Mild Energy Restriction and n-3 Polyunsaturated Fatty Acid Deficiency in Juvenile Rats.Nutrients · 2017Article
- Thyroid Hormone Induces PGC-1α during Dendritic Outgrowth in Mouse Cerebellar Purkinje Cells.Frontiers in cellular neuroscience · 2017Article
- Mosaic Expression of Thyroid Hormone Regulatory Genes Defines Cell Type-Specific Dependency in the Developing Chicken Cerebellum.Cerebellum (London, England) · 2016Article
- Effects of Gadolinium-Based Contrast Agents on Thyroid Hormone Receptor Action and Thyroid Hormone-Induced Cerebellar Purkinje Cell Morphogenesis.Frontiers in endocrinology · 2016Article
- Hypothyroidism and brain developmental players.Thyroid research · 2015Article
- Hypothyroidism alters antioxidant defence system in rat brainstem during postnatal development and adulthood.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- Modulation of antioxidant enzyme expression by PTU-induced hypothyroidism in cerebral cortex of postnatal rat brain.Neurochemical research · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone plays a crucial role in cerebellar development. Deficiency of thyroid hormone results in abnormal cerebellar growth and differentiation. In rodent, thyroid hormone mainly affects cerebellar development during the first 2 weeks of postnatal life. Thyroid hormone replacement after such critical period cannot fully rescue abnormal cerebellar development induced by perinatal hypothyroidism. Thyroid hormone receptor (TR) is a ligand-regulated transcription factor that binds to a specific DNA sequence called thyroid-hormone-responsive element. TR recruits various coregulators such as coactivator and corepressor in a ligand-dependent manner to regulate transcription of target genes. In cerebellum, at least three different TRs are expressed in a cell-specific manner. TRbeta1 is expressed predominantly in the Purkinje cell, whereas TRalpha1 in other subset of neurons. Although these TRs are widely expressed during the cerebellar development and their levels are greater in adult, the expression of many thyroid-hormone-responsive genes is altered by thyroid hormone status only during early postnatal critical period. Not only the expression levels of TRs but also those of cofactors and other nuclear receptors may play a role in regulating thyroid hormone sensitivity in the developing cerebellum. In this article, the effect of thyroid hormone on morphological development of cerebellum and molecular mechanisms of thyroid hormone action are introduced. Furthermore, possible involvement of other nuclear receptors and cofactors in thyroid hormone action in the developing cerebellum is also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.