ArticleHippokratia2008
Periodontitis as a risk factor for cardiovascular disease: the role of anti-phosphorylcholine and anti-cardiolipin antibodies.
Article in Hippokratia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Oral Microbiota Linking Humoral Response, Periodontitis and Atherosclerosis.Journal of clinical periodontology · 2025Article
- Effect of non-surgical periodontal therapy on CD14 + CD16+ monocyte counts in peripheral blood samples: a clinical interventional study.BMC oral health · 2024Article
- Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice.International journal of stroke : official journal of the International Stroke Society · 2020Article
- LL-37-Induced Autophagy Contributed to the Elimination of LiveFrontiers in cellular and infection microbiology · 2020Article
- Review
- Clinical validation and assessment of a modular fluorescent imaging system and algorithm for rapid detection and quantification of dental plaque.BMC oral health · 2017Article
- Assessment of pathogenesis of infective endocarditis by plasma IgG antibody titer test against periodontal bacteria.Clinical case reports · 2017Article
- Anti-phospholipid Antibodies and Smoking: An Overview.Clinical reviews in allergy & immunology · 2017Review
- Evaluation of serum anti-cardiolipin antibodies after non-surgical periodontal treatment in chronic periodontitis patients.Odontology · 2015Article
- CRP and IL-1B Gene Polymorphisms and CRP in Blood in Periodontal Disease.The open dentistry journal · 2013Article
- Oral health conditions and frailty in Mexican community-dwelling elderly: a cross sectional analysis.BMC public health · 2012Article
- Diabetes and hypertension: is there a common metabolic pathway?Current atherosclerosis reports · 2012Review
- Autoantibodies to the β(1)-Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction.ISRN dentistry · 2011Article
- Lipoproteins and lipoprotein metabolism in periodontal disease.Clinical lipidology · 2010Article
- Comparative evaluation of serum heat shock protein 60 in chronic periodontitis patients with and without coronary heart disease - A case-control study.Journal of Indian Society of PeriodontologyArticle
- Evaluation of anticardiolipin antibodies in tobacco users and non-tobacco users with severe chronic periodontal disease.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Available evidence does allow an interpretation of periodontitis as being a risk factor for atherosclerosis and coronary heart disease. There is now a convincing body of evidence that mechanism of atherosclerosis has a major inflammatory component and it is much more than the simple accumulation of lipids on the vascular walls. Studies have shown that certain other mild bacterial infections consist a major risk factor for stroke in young and middle aged patients. Several possible mechanisms could explain the observed association between infection and infraction. The evidence supports the premise that periodontitis leads to systemic exposure to oral bacteria and that the resulting production of inflammatory mediators is capable of initiating or supporting mechanisms associated to development of atherosclerosis and coronary heart disease. Studies in patients with pathologic concentrations of anti-cardiolipin and anti-phosphorylcholine antibodies demonstrated increased pocket depth and attachment loss, compared to patients with normal levels of the above antibodies. These antibodies could be associated to increased risk for stroke and atherosclerosis in patients with periodontitis. As we become more familiar to the association between periodontitis and cardiovascular disease it is likely that in the future periodontal disease may be added to the list of the factors which are used to assess patients' risk profile for coronary heart disease and stroke.
Indexed as
Identifiers
18923669PMC2504402W2464967924What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.