ReviewNature reviews. Microbiology2008
CD4 immunophenotyping in HIV infection.
Review in Nature reviews. Microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- CD4 enumeration technologies: a systematic review of test performance for determining eligibility for antiretroviral therapy.PloS one · 2015Pooled it
- Microfluidic Assays for CD4 T Lymphocyte Counting: A Review.Biosensors · 2025Review
- Article
- Advanced immunophenotyping of lymphocyte and monocyte subsets in healthy Australian adults using a novel spectral flow cytometry panel.Frontiers in immunology · 2025Article
- Using Spectral Flow Cytometry for CAR T-Cell Clinical Trials: Game Changing Technologies Enabling Novel Therapies.International journal of molecular sciences · 2024Review
- The development, evaluation, performance, and validation of micro-PCR and extractor for the quantification of HIV-1 &-2 RNA.Scientific reports · 2024Article
- Application and interpretation of immunophenotyping data in safety and risk assessment.Frontiers in toxicology · 2024Review
- Performance Evaluation of Microscanner Plus, an Automated Image-Based Cell Counter, for Counting CD4+ T Lymphocytes in HIV Patients.Diagnostics (Basel, Switzerland) · 2023Article
- A bibliometric analysis: CaFrontiers in immunology · 2023Review
- The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China.Immunity & ageing : I & A · 2022Article
- Measurement of circulating CD21Scientific reports · 2022Article
- Bioinspired membrane-based nanomodulators for immunotherapy of autoimmune and infectious diseases.Acta pharmaceutica Sinica. B · 2022Review
- Dynamic analysis of immune status in patients with intracranial germ cell tumor and establishment of an immune risk prognostic model.Frontiers in immunology · 2022Article
- Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon.Scientific reports · 2021Article
- Validation of the BD FACSPresto system for the measurement of CD4 T-lymphocytes and hemoglobin concentration in HIV-negative and HIV-positive subjects.Scientific reports · 2020Article
- Review
- External Quality Assessment on CD4+ T-Cell Count Using in-House Proficiency Testing Panels for CD4 Count Laboratories in Addis Ababa, Ethiopia.Ethiopian journal of health sciences · 2019Article
- Single-Cell High-Throughput Technologies in Cerebrospinal Fluid Research and Diagnostics.Frontiers in immunology · 2019Review
- Toward Precision Healthcare: Context and Mathematical Challenges.Frontiers in physiology · 2017Article
- Aging of immune system: Immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults.Aging · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The ability to rapidly identify immune cell subsets such as CD4 cells, which became possible around the same time as the onset of the HIV/AIDS pandemic, was one of the greatest advances in clinical and diagnostic immunology. The evolution of this global pandemic and the subsequent development of treatment strategies to prolong the life of infected individuals mean that it is now more crucial than ever that we develop affordable, reliable and accurate methods for the enumeration of CD4 cells. Here, we provide an overview of the historical developments in CD4 enumeration technologies that are related to HIV infection, and summarize the current technological challenges that must be overcome to meet the needs of those living with HIV infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.