Evidence map›Paper›PMID 18923182›Full record

ReviewPhysiological reviews2008

Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production.

Scott K Powers, Malcolm J Jackson

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiological reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03540602 (Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise), which is not on this map. Cited by 1,058 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,058citing papers in PubMed, 10 pooled it
77.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03540602 phase1unknown statusnot on this mapstarted 2018, after this paper: background citation

Polyphenol Rich Supplementation on Markers of Recovery From Intense Resistance Exercise

TypeinterventionalSponsorJacksonville UniversityRan2018 to 2018Enrolled20ConditionsMuscle SorenessArmsTart Cherry, Placebo Oral Capsule [CEBOCAP]
3 · Its place in the literature

Who cites it

1,058 citing papers in PubMed, 10 syntheses or guidelines pooled it, 2,342 citations in OpenAlex.

  1. Pooled it
  2. Effects ofNutrients · 2026
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  8. Effects of Maca (Nutrients · 2024
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  20. International journal of medical sciences · 2026
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998 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Scott K PowersDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA. spowers@hhp.ufl.edu
Malcolm J Jackson
University of Florida · US

Funding

Exercise, Antioxidants, and I-R InjuryR01HL067855 · NHLBI · UNIVERSITY OF FLORIDA · PI POWERS, SCOTT K. · 2003 to 2006
$1.3M
Medical Research Council G0700919NHLBI NIH HHS R01 HL067855
6 · The paper itself

Abstract

The first suggestion that physical exercise results in free radical-mediated damage to tissues appeared in 1978, and the past three decades have resulted in a large growth of knowledge regarding exercise and oxidative stress. Although the sources of oxidant production during exercise continue to be debated, it is now well established that both resting and contracting skeletal muscles produce reactive oxygen species and reactive nitrogen species. Importantly, intense and prolonged exercise can result in oxidative damage to both proteins and lipids in the contracting myocytes. Furthermore, oxidants can modulate a number of cell signaling pathways and regulate the expression of multiple genes in eukaryotic cells. This oxidant-mediated change in gene expression involves changes at transcriptional, mRNA stability, and signal transduction levels. Furthermore, numerous products associated with oxidant-modulated genes have been identified and include antioxidant enzymes, stress proteins, DNA repair proteins, and mitochondrial electron transport proteins. Interestingly, low and physiological levels of reactive oxygen species are required for normal force production in skeletal muscle, but high levels of reactive oxygen species promote contractile dysfunction resulting in muscle weakness and fatigue. Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction.

Indexed as

AnimalsAntioxidantsExerciseFree RadicalsHumansMuscle ContractionMuscle FatigueMuscle Fibers, SkeletalMuscle, SkeletalOxidative StressAntioxidantsFree Radicals

Identifiers

PMID18923182
PMCPMC2909187
OpenAlexW2113529945

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.