ArticleProceedings of the National Academy of Sciences of the United States of America2008
A host dicer is required for defective viral RNA production and recombinant virus vector RNA instability for a positive sense RNA virus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 85 citations in OpenAlex.
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- A Novel Heptasegmented Positive-Sense Single-Stranded RNA Virus from the Phytopathogenic FungusJournal of virology · 2022Article
- Molecular and Biological Characterization of the First Mymonavirus Identified inFrontiers in microbiology · 2022Article
- Transcriptome analysis implicates secondary metabolite production, redox reactions, and programmed cell death during allorecognition in Cryphonectria parasitica.G3 (Bethesda, Md.) · 2021Article
- Infection of Two Heterologous Mycoviruses Reduces the Virulence ofFrontiers in microbiology · 2021Article
- The Evolutionary Significance of RNAi in the Fungal Kingdom.International journal of molecular sciences · 2020Review
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- Identification of a Novel Hypovirulence-Inducing Hypovirus FromFrontiers in microbiology · 2019Article
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- Diverse, Novel Mycoviruses From the Virome of a HypovirulentFrontiers in plant science · 2018Article
- The role of co-opted ESCRT proteins and lipid factors in protection of tombusviral double-stranded RNA replication intermediate against reconstituted RNAi in yeast.PLoS pathogens · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Defective interfering (DI) RNAs, helper virus-dependent deletion mutant RNAs derived from the parental viral genomic RNA during replication, have been described for most RNA virus taxonomic groups. We now report that DI RNA production in the chestnut blight fungus, Cryphonectria parasitica, persistently infected by virulence-attenuating positive sense RNA hypoviruses, depends on one of two host dicer genes, dcl-2. We further report that nonviral sequences that are rapidly deleted from recombinant hypovirus RNA virus vectors in wild-type and dicer gene dcl-1 deletion mutant strains are stably maintained and expressed in the Deltadcl-2 mutant strain. These results establish a requirement for dcl-2, the C. parasitica dicer gene responsible for antiviral defense and generation of virus-derived small interfering RNAs, in DI RNA production and recombinant virus vector RNA instability.
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