ArticleMolecular biology and evolution2009
An investigation of the statistical power of neutrality tests based on comparative and population genetic data.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent adaptive events in human brain revealed by meta-analysis of positively selected genes.PloS one · 2013Pooled it
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- Evolution under a model of functionally buffered deleterious mutations can lead to positive selection in protein-coding genes.Evolution; international journal of organic evolution · 2023Article
- Power of neutrality tests for detecting natural selection.G3 (Bethesda, Md.) · 2023Article
- North African fox genomes show signatures of repeated introgression and adaptation to life in deserts.Nature ecology & evolution · 2023Article
- Mitogenomic Features and Evolution of the Nile River Dominant Tilapiine Species (Perciformes: Cichlidae).Biology · 2022Article
- Evolutionary analysis of rabies virus isolates from Georgia.Archives of virology · 2022Article
- Functional Divergence of the bag-of-marbles Gene in the Drosophila melanogaster Species Group.Molecular biology and evolution · 2022Article
- Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.medRxiv : the preprint server for health sciences · 2021Article
- Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.Research square · 2021Article
- Molecular footprints of selection effects and whole genome duplication (WGD) events in three blueberry species: detected by transcriptome dataset.BMC plant biology · 2020Article
- Classifying evolutionary forces in language change using neural networks.Evolutionary human sciences · 2020Article
- Comparative genomics provides new insights into the remarkable adaptations of the African wild dog (Lycaon pictus).Scientific reports · 2019Article
- Alternated selection mechanisms maintain adaptive diversity in different demographic scenarios of a large carnivore.BMC evolutionary biology · 2019Article
- Mapping the Evolutionary Potential of RNA Viruses.Cell host & microbe · 2018Review
- Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans.PloS one · 2018Article
- Genome-wide signals of positive selection in strongylocentrotid sea urchins.BMC genomics · 2017Article
- Natural Selection in the Great Apes.Molecular biology and evolution · 2016Article
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3 authors.
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Abstract
In this report, we investigate the statistical power of several tests of selective neutrality based on patterns of genetic diversity within and between species. The goal is to compare tests based solely on population genetic data with tests using comparative data or a combination of comparative and population genetic data. We show that in the presence of repeated selective sweeps on relatively neutral background, tests based on the d(N)/d(S) ratios in comparative data almost always have more power to detect selection than tests based on population genetic data, even if the overall level of divergence is low. Tests based solely on the distribution of allele frequencies or the site frequency spectrum, such as the Ewens-Watterson test or Tajima's D, have less power in detecting both positive and negative selection because of the transient nature of positive selection and the weak signal left by negative selection. The Hudson-Kreitman-Aguadé test is the most powerful test for detecting positive selection among the population genetic tests investigated, whereas McDonald-Kreitman test typically has more power to detect negative selection. We discuss our findings in the light of the discordant results obtained in several recently published genomic scans.
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