ArticleMolecular brain2008
beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones.
Article in Molecular brain, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- From glia limitans to glial scars: in vitro co-culture studies of the astrocyte and meningeal interaction.Fluids and barriers of the CNS · 2025Pooled it
- Axonal growth inhibitors and their receptors in spinal cord injury: from biology to clinical translation.Neural regeneration research · 2023Review
- Review
- ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation.Cell & bioscience · 2023Article
- Serotonin transporter-mediated molecular axis regulates regional retinal ganglion cell vulnerability and axon regeneration after nerve injury.PLoS genetics · 2021Article
- One Raft to Guide Them All, and in Axon Regeneration Inhibit Them.International journal of molecular sciences · 2021Review
- MAG induces apoptosis in cerebellar granule neurons through p75Cell death & disease · 2019Article
- Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool.Cell stem cell · 2018Article
- Integrins promote axonal regeneration after injury of the nervous system.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Rab23 Regulates Radial Migration of Projection Neurons via N-cadherin.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Sialic Acid Is Required for Neuronal Inhibition by Soluble MAG but not for Membrane Bound MAG.Frontiers in molecular neuroscience · 2016Article
- Sialic Acids on Varicella-Zoster Virus Glycoprotein B Are Required for Cell-Cell Fusion.The Journal of biological chemistry · 2015Article
- Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Article
- Insights into the physiological role of CNS regeneration inhibitors.Frontiers in molecular neuroscience · 2015Review
- Myelin-associated inhibitors in axonal growth after CNS injury.Current opinion in neurobiology · 2014Review
- Integrins and cAMP mediate netrin-induced growth cone collapse.Brain research · 2013Article
- Where no synapses go: gatekeepers of circuit remodeling and synaptic strength.Trends in neurosciences · 2013Review
- Class 3 semaphorin mediates dendrite growth in adult newborn neurons through Cdk5/FAK pathway.PloS one · 2013Article
- LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin.Journal of cell science · 2013Article
- Differential distribution of major brain gangliosides in the adult mouse central nervous system.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Several myelin-associated factors that inhibit axon growth of mature neurons, including Nogo66, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), can associate with a common GPI-linked protein Nogo-66 receptor (NgR). Accumulating evidence suggests that myelin inhibitors also signal through unknown NgR-independent mechanisms. Here we show that MAG, a RGD tri-peptide containing protein, forms a complex with β1-integrin to mediate axonal growth cone turning responses of several neuronal types. Mutations that alter the RGD motif in MAG or inhibition of β1-integrin function, but not removal of NgRs, abolish these MAG-dependent events. In contrast, OMgp-induced repulsion is not affected by inhibition of b1-integrin function. We further show that MAG stimulates tyrosine phosphorylation of focal adhesion kinase (FAK), which in turn is required for MAG-induced growth cone turning. These studies identify β1-integrin as a specific mediator for MAG in growth cone turning responses, acting through FAK activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.