ArticleJournal of neuroinflammation2008
Hematopoietic cell activation in the subventricular zone after Theiler's virus infection.
Article in Journal of neuroinflammation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Galectin-3 in the Lateral Ventricle Regulates Immune Functions.ASN neuro · 2026Review
- Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion.Stem cell reports · 2025Article
- Review
- Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis.Journal of neuroinflammation · 2020Article
- Promoting Myelin Repair through In Vivo Neuroblast Reprogramming.Stem cell reports · 2018Article
- Therapeutic potential of extracellular vesicles derived from human mesenchymal stem cells in a model of progressive multiple sclerosis.PloS one · 2018Article
- Calretinin interneuron density in the caudate nucleus is lower in autism spectrum disorder.Brain : a journal of neurology · 2017Article
- Cuprizone demyelination induces a unique inflammatory response in the subventricular zone.Journal of neuroinflammation · 2016Article
- Article
- Use of induced pluripotent stem cell derived neurons engineered to express BDNF for modulation of stressor related pathology.Frontiers in cellular neuroscience · 2014Article
- Cellular and molecular determinants of stroke-induced changes in subventricular zone cell migration.Antioxidants & redox signaling · 2011Review
- Viral models of multiple sclerosis: neurodegeneration and demyelination in mice infected with Theiler's virus.Progress in neurobiologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe periventricular subventricular zone (SVZ) contains stem cells and is an area of active neurogenesis and migration. Since inflammation can reduce neurogenesis, we tested whether Theiler's murine encephalomyelitis virus (TMEV) induces inflammation and reduces neurogenesis in the SVZ.
methodsWe performed immmunohistochemistry for the hematopoietic cell marker CD45 throughout the central nervous system and then examined neuroblasts in the SVZ.
resultsCD45+ activation (inflammation) occurred early in the forebrain and preceded cerebellar and spinal cord inflammation. Inflammation in the brain was regionally stochastic except for the SVZ and surrounding periventricular regions where it was remarkably pronounced and consistent. In preclinical mice, SVZ neuroblasts emigrated into inflamed periventricular regions. The number of proliferating phoshpohistone3+ cells and Doublecortin+ (Dcx) SVZ neuroblasts was overall unaffected during the periods of greatest inflammation. However the number of Dcx+ and polysialylated neural cell adhesion molecule (PSA-NCAM+) SVZ neuroblasts decreased only after periventricular inflammation abated.
conclusionOur results suggest that after TMEV infection, the SVZ may mount an attempt at neuronal repair via emigration, a process dampened by decreases in neuroblast numbers.
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