ArticleThe Journal of infectious diseases2008
Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 103 citations in OpenAlex.
- Identification and profiling of HLA-A*02:01-restrictedVirulence · 2026Article
- Validation of novel conditional ligands and large-scale detection of antigen-specific T cells for H-2DScientific reports · 2024Article
- Immunotherapy targeting the PD-1 pathway alleviates neuroinflammation caused by chronic Toxoplasma infection.Scientific reports · 2023Article
- Understanding neuroinflammation through central nervous system infections.Current opinion in neurobiology · 2022Review
- Article
- Peptide Centric Vβ Specific Germline Contacts Shape a Specialist T Cell Response.Frontiers in immunology · 2022Article
- Protective Immunity AgainstFrontiers in veterinary science · 2021Article
- The immune system utilizes two distinct effector mechanisms of T cells depending on two different life cycle stages of a single pathogen, Toxoplasma gondii, to control its cerebral infection.Parasitology international · 2020Review
- Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons.Cell reports · 2019Article
- Review
- Rhoptry and Dense Granule Secreted Effectors Regulate CD8Frontiers in immunology · 2019Article
- Immunogenicity of a Virus-Like-Particle Vaccine Containing Multiple Antigenic Epitopes ofFrontiers in immunology · 2019Article
- T Cell Receptor-Major Histocompatibility Complex Interaction Strength Defines Trafficking and CD103Frontiers in immunology · 2018Article
- Identification of a Novel CD8 T Cell Epitope Derived fromFrontiers in immunology · 2018Article
- Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8Cancer research · 2017Article
- Brains and Brawn: Toxoplasma Infections of the Central Nervous System and Skeletal Muscle.Trends in parasitology · 2017Review
- Determination of a Key Antigen for Immunological Intervention To Target the Latent Stage ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- CD103Frontiers in immunology · 2017Article
- Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.Open biology · 2016Article
- Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden.Immunology · 2016Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBALB/c mice control infection with the obligate intracellular parasite Toxoplasma gondii and develop a latent chronic infection in the brain, as do immunocompetent humans. Interferon-gamma-producing CD8+ T cells provide essential protection against T. gondii infection, but the epitopes recognized have so far remained elusive.
methodsWe employed caged major histocompatibility complex molecules to generate approximately 250 H-2L(d) tetramers and to distinguish T. gondii-specific CD8+ T cells in BALB/c mice.
resultsWe identified 2 T. gondii-specific H-2L(d)-restricted T cell epitopes, one from dense granule protein GRA4 and the other from rhoptry protein ROP7. H-2L(d)/GRA4 reactive T cells from multiple organ sources predominated 2 weeks after infection, while the reactivity of the H-2L(d)/ROP7 T cells peaked 6-8 weeks after infection. BALB/c animals infected with T. gondii mutants defective in establishing a chronic infection showed altered levels of antigen-specific T cells, depending on the T. gondii mutant used.
conclusionsOur results shed light on the identity and the parasite stage-specificity of 2 CD8+ T cell epitopes recognized in the acute and chronic phase of infection with T. gondii.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.