ArticlePflugers Archiv : European journal of physiology1991
Modulation of calcium movements by nitroprusside in isolated vascular smooth muscle cells.
Article in Pflugers Archiv : European journal of physiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 121 citations in OpenAlex.
- Article
- Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Role of T-type channels in vasomotor function: team player or chameleon?Pflugers Archiv : European journal of physiology · 2014Review
- A Ca²⁺-dependent chloride current and Ca²⁺ influx via Ca(v)1.2 ion channels play major roles in P2Y receptor-mediated pulmonary vasoconstriction.British journal of pharmacology · 2012Article
- New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling.American journal of physiology. Heart and circulatory physiology · 2012Review
- Hypoxic pulmonary vasoconstriction.Physiological reviews · 2012Review
- Contractile and electrophysiological properties of pulmonary artery smooth muscle are not altered in TASK-1 knockout mice.The Journal of physiology · 2011Article
- Functional evidence of a role for two-pore domain potassium channels in rat mesenteric and pulmonary arteries.British journal of pharmacology · 2004Article
- Endothelium-dependent frequency modulation of Ca2+ signalling in individual vascular smooth muscle cells of the rat.The Journal of physiology · 1997Article
- Basal release of nitric oxide induces an oscillatory motor pattern in canine colon.The Journal of physiology · 1997Article
- Voltage-gated calcium channel currents in human coronary myocytes. Regulation by cyclic GMP and nitric oxide.The Journal of clinical investigation · 1997Article
- Force and intracellular Ca2+ during cyclic nucleotide-mediated relaxation of rat anococcygeus muscle and the effects of cyclopiazonic acid.British journal of pharmacology · 1996Article
- Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Inhibition by sodium nitroprusside of a calcium store depletion-activated non-selective cation current in smooth muscle cells of the mouse anococcygeus.British journal of pharmacology · 1996Article
- Photosensitization of oesophageal smooth muscle by 3-NO2-1, 4-dihydropyridines: evidence for two cyclic GMP-dependent effector pathways.British journal of pharmacology · 1995Article
- Endothelium-dependent relaxations in sheep pulmonary arteries and veins: resistance to block by NG-nitro-L-arginine in pulmonary hypertension.British journal of pharmacology · 1995Article
- Control of pulmonary vascular smooth muscle tone by sarcoplasmic reticulum Ca2+ pump blockers: thapsigargin and cyclopiazonic acid.Pflugers Archiv : European journal of physiology · 1995Article
- Cyclic GMP-mediated inhibition of L-type Ca2+ channel activity by human natriuretic peptide in rabbit heart cells.British journal of pharmacology · 1995Article
- Tonic inhibition of neuronal calcium channels by G proteins removed during whole-cell patch-clamp experiments.Pflugers Archiv : European journal of physiology · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using the patch-clamp technique, we have characterised the inward current from enzymatically dispersed rabbit pulmonary arterial cells, and investigated the effects of the vasodilator, nitroprusside (NP), on these and other membrane currents. With Cs(+)-filled pipettes, inward currents were recorded during brief depolarizing voltage steps in both physiological Ca2+ and 10 mM Ba2+. The threshold for current activation was positive to -40 mV and the current peaked at 0 mV for Ca2+ and +10 mV for Ba2+. During the first few minutes of recording, inward currents increased or "ran-up". This could not be attributed to blockade of outward current or the inclusion of adenosine triphosphate (ATP) in the patch pipette. Experiments revealed that all the inward current was carried through a single type of voltage-activated Ca2+ channel, namely the high-threshold, dihydropyridine-sensitive channel. It was unaffected by tetrodotoxin but was abolished at all potentials by low concentrations of Cd2+ (100 microM) or nifedipine (1-2 microM). NP (1 microM) suppressed peak inward Ba2+ current at +10 mV by approximately 45%. Higher concentrations (50 microM) did not produce further blockade of the current. This decrease was associated with increased inactivation of the current, and both effects required the presence of ATP in the patch pipette. In physiological Ca2+, using K(+)-filled pipettes, NP was found to induce spontaneous bursts of outward currents, which are probably activated by the release of Ca2+ from Ca(2+)-overloaded stores. These results are consistent with NP lowering cytosolic Ca2+, and hence causing vasodilation, by inhibiting Ca2+ influx through voltage-gated Ca2+ channels and by promoting Ca2+ uptake into the sarcoplasmic reticulum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.