ArticleThe Journal of clinical investigation1991
Endobronchial allergen challenge in asthma. Demonstration of cellular source of granulocyte macrophage colony-stimulating factor by in situ hybridization.
Article in The Journal of clinical investigation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- Cytokine expression in allergic inflammation: systematic review of in vivo challenge studies.Mediators of inflammation · 2003Pooled it
- Trial
- A phase 1, randomized, placebo-controlled, dose-escalation study of an anti-IL-13 monoclonal antibody in healthy subjects and mild asthmatics.British journal of clinical pharmacology · 2013Trial
- Protein Translation and Signaling in Human Eosinophils.Frontiers in medicine · 2017Review
- Diagnosis and management of eosinophilic asthma: a US perspective.Journal of asthma and allergy · 2014Review
- Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Decreased levels of soluble Toll-like Receptor 2 in patients with asthma.Reports of biochemistry & molecular biology · 2012Article
- GM-CSF differentially regulates eosinophil and neutrophil adhesive interactions with vascular endothelium in vivo.Iranian journal of allergy, asthma, and immunology · 2010Article
- Cytokine and anti-cytokine therapy in asthma: ready for the clinic?Clinical and experimental immunology · 2009Review
- Article
- CD48 is critically involved in allergic eosinophilic airway inflammation.American journal of respiratory and critical care medicine · 2007Article
- Stimulus-dependent glucocorticoid-resistance of GM-CSF production in human cultured airway smooth muscle.British journal of pharmacology · 2005Article
- Pathophysiological mechanisms of asthma. Application of cell and molecular biology techniques.Molecular biotechnology · 2001Review
- Cytokines in asthma.Thorax · 1999Review
- Granulocyte-macrophage colony-stimulating factor and interleukin-3 cause basophil histamine release by a common pathway: downregulation by sodium.Immunology · 1999Article
- Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation.Clinical and experimental immunology · 1998Article
- Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.The Journal of clinical investigation · 1996Article
- Cytokines induce selective granulocyte chemotactic responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 1996Article
- Alpha 4 integrin-induced cytokine production and eosinophil function.Springer seminars in immunopathology · 1995Review
- Dexamethasone up-regulates granulocyte-macrophage colony-stimulating factor receptor expression on human monocytes.Immunology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Airway inflammation is thought to play an important role in the pathogenesis of asthma. We have used in situ hybridization and an immunoassay to determine whether granulocyte macrophage colony-stimulating factor (GM-CSF) (a cytokine capable of eosinophil activation) is present in the airway of asthmatics (n = 6) who have 37.0 +/- 15.1% airway eosinophilia after endobronchial allergen challenge. Levels of immunoreactive GM-CSF (less than 4 pg/ml pre-allergen versus 180.5 +/- 46.9 pg/ml post-allergen) increased significantly 24 h after endobronchial allergen stimulation. The cellular source of bronchoalveolar lavage (BAL) GM-CSF, as determined by in situ hybridization and immunoperoxidase staining, was derived predominantly from UCHL-1 positive BAL lymphocytes, as well as from a smaller population of alveolar macrophages. Before local endobronchial allergen challenge, less than 1% of lymphocytes and alveolar macrophages recovered by BAL expressed GM-CSF mRNA, whereas after allergen stimulation 92.6 +/- 3.4% of lymphocytes and 17.5 +/- 22.7% of alveolar macrophages expressed GM-CSF mRNA. This study provides evidence that in an experimental model of allergen-induced asthma, activation of the immune and inflammatory response (BAL lymphocyte and alveolar macrophage production of GM-CSF) is temporally associated with an inflammatory cell influx of eosinophils into the airway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.