SynthesisWorld journal of gastroenterology2008
A systematic review and meta-analysis of the Chinese literature for the treatment of achalasia.
Synthesis in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Comprehensive evaluation of current strategies in achalasia treatment: Insights from an umbrella review.Medicine · 2025Pooled it
- SAGES guidelines for the surgical treatment of esophageal achalasia.Surgical endoscopy · 2012Guideline
- Long-term efficacy of modified retrievable stents for treatment of achalasia cardia.Surgical endoscopy · 2016Trial
- Efficacy and safety of Guanxin Danshen dropping pills for the treatment of angina pectoris: a meta-analysis.American journal of translational research · 2025Review
- Peroral endoscopic myotomy: an evolving treatment for achalasia.Nature reviews. Gastroenterology & hepatology · 2015Review
- Childhood achalasia: A comprehensive review of disease, diagnosis and therapeutic management.World journal of gastrointestinal endoscopy · 2014Review
- Robotic-assisted Heller myotomy versus laparoscopic Heller myotomy for the treatment of esophageal achalasia: a case-control study.Journal of robotic surgery · 2012Article
- Treatment and surveillance strategies in achalasia: an update.Nature reviews. Gastroenterology & hepatology · 2011Review
- Endoscope-guided pneumatic dilation for treatment of esophageal achalasia.World journal of gastroenterology · 2010Review
- Achalasia: a review of Western and Iranian experiences.World journal of gastroenterology · 2009Review
- Current clinical approach to achalasia.World journal of gastroenterology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the effect of different approaches in the treatment of achalasia in China.
methodsWe performed a systematic review and meta-analysis of Chinese literature by searching the Chinese Biomedical Database and Chinese scientific Journals database (up to March 2008). All cohort studies (controlled or uncontrolled) in which the patients were observed for more than a year were reviewed in detail. Dichotomous outcomes were reported as relative risks (RR) with 95% confidence interval (CI) for controlled trials. The efficacy in uncontrolled trials was assessed by a pooled estimate of response rate with individual studies weighted in proportion to the sample size.
resultsSeven controlled trials compared the effect of botulinum toxin injection (BoTx) with pneumatic dilation (PD). PD was superior to BoTx [65.2% vs 45.3%; RR 1.47 (95% CI 1.23-1.77), P < 0.0001], and had a lower clinical relapse rate (BoTx 30.2% vs PD 10%, RR 0.32 (0.16-0.65), P = 0.001). Heller myotomy (HM) had superior remission rate compared to PD [HM 94.0% vs PD 64.1%, RR 1.48 (1.15-1.99), P = 0.002]. In uncontrolled trials, the effectiveness of PD was 86.6% (23.9%) vs 94.8% (10.6%) for HM. The main complications of PD were perforation and gastroesophageal reflux disease.
conclusionHM is the most effective long-term treatment for patients with achalasia in China. In the future, controlled clinical trials on the treatment of achalasia should focus on comparing laparoscopic myotomy with or without antireflux procedure, including different partial and total fundoplication techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.