ArticleWorld journal of gastroenterology2008
Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Human umbilical cord blood mesenchymal stem cells as a potential therapy for schistosomal hepatic fibrosis: an experimental study.Pathogens and global health · 2023Article
- Hepatosplenic Protective Actions ofFrontiers in veterinary science · 2021Article
- Adoptive Transfer of Bone Marrow-Derived Monocytes Ameliorates Schistosoma mansoni -Induced Liver Fibrosis in Mice.Scientific reports · 2019Article
- Therapeutic potential effect of bone marrow-derived mesenchymal stem cells on chronic liver disease in murineJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
- Complementary Effect ofHelminthologia · 2018Article
- Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin, TGF-β1, IL-13 and oxidative stress.World journal of gastroenterology · 2017Article
- Therapeutic Potential of Bone Marrow-Derived Mesenchymal Stem Cells on Experimental Liver Injury Induced by Schistosoma mansoni: A Histological Study.International journal of stem cells · 2016Article
- Propolis enhances the effectiveness of praziquantel in experimental schistosomiasis: biochemical and histopathological study.Parasitology research · 2014Article
- Ameliorative effect of bone marrow-derived stem cells on injured liver of mice infected with Schistosoma mansoni.The Korean journal of parasitology · 2014Article
- Bone marrow progenitor cells do not contribute to liver fibrogenic cells.World journal of hepatology · 2012Article
- Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis.Parasites & vectors · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the potential of bone marrow mononuclear cells (BM-MCs) in the regeneration of hepatic lesions induced by Schistosoma mansoni (S.mansoni) chronic infection.
methodsFemale mice chronically infected with S.mansoni were treated with BM-MCs obtained from male green fluorescent protein (GFP) transgenic mice by intravenous or intralobular injections. Control mice received injections of saline in similar conditions. Enzyme-linked immunosorbent assay (ELISA) assay for transforming growth factor-beta (TGF-beta), polymerase chain reaction (PCR) for GFP DNA, immunofluorescence and morphometric studies were performed.
resultsTransplanted GFP(+) cells migrated to granuloma areas and reduced the percentage of liver fibrosis. The presence of donor-derived cells was confirmed by fluorescence in situ hybridization (FISH) analysis for detection of cells bearing Y chromosome and by PCR analysis for detection of GFP DNA. The levels of TGF-beta, a cytokine associated with fibrosis deposition, in liver fragments of mice submitted to therapy were reduced. The number of oval cells in liver sections of S.mansoni-infected mice increased 3-4 fold after transplantation. A partial recovery in albumin expression, which is decreased upon infection with S.mansoni, was found in livers of infected mice after cellular therapy.
conclusionIn conclusion, transplanted BMCs migrate to and reduce the damage of chronic fibrotic liver lesions caused by S.mansoni.
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