ArticleAddiction (Abingdon, England)2008
Early-onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescent Finnish twins.
Article in Addiction (Abingdon, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Ultra-brief breath counting (mindfulness) training promotes recovery from stress-induced alcohol-seeking in student drinkers.Addictive behaviors · 2020Trial
- Reduced substance use as a secondary benefit of an indicated cognitive-behavioral adolescent depression prevention program.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2012Trial
- Onset of alcohol or substance use disorders following treatment for adolescent depression.Journal of consulting and clinical psychology · 2012Trial
- Enduring effects of prenatal and infancy home visiting by nurses on children: follow-up of a randomized trial among children at age 12 years.Archives of pediatrics & adolescent medicine · 2010Trial
- Patterns, Predictors, and Correlates of Problematic Alcohol Use and Remission From Adolescence to Early Midlife.Alcohol, clinical & experimental research · 2026Article
- Ethanol-Induced Depression: Exploring the Underlying Molecular Mechanisms.Cellular and molecular neurobiology · 2025Review
- Indirect effects of perceived stress and depression on the relationship between insomnia symptoms and hazardous drinking.Alcohol (Fayetteville, N.Y.) · 2025Observational
- Developmental trajectories of child and adolescent emotional problems: associations with early adult alcohol use behaviors.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Substance Use-Related Factors and Recurrent Depression among Former Adolescent Psychiatric Inpatients.European addiction research · 2025Article
- Association Between Self-Reported Oral Health and Dental Fear Among Illicit Drug Users in Northern Finland.Clinical and experimental dental research · 2024Article
- The Association Between Personality Traits and Substance Use Among Advanced Level Students in Western Province, Sri Lanka: A Cross-sectional Study.Addiction & health · 2024Article
- Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals.Psychological medicine · 2024Article
- Individual Trajectories of Depressive Symptoms Within Racially-Ethnically Diverse Youth: Associations with Polygenic Risk for Depression and Substance Use Intent and Perceived Harm.Behavior genetics · 2024Article
- The dose-effect relationships of cigarette and alcohol consumption with depressive symptoms: a multiple-center, cross-sectional study in 5965 Chinese middle-aged and elderly men.BMC psychiatry · 2022Article
- The relationship between smokeless tobacco (snus) and anxiety and depression among adults and elderly people. A comparison to smoking in the Tromsø Study.Addiction (Abingdon, England) · 2022Article
- Adverse childhood experiences and adolescent drug use in the UK: The moderating role of socioeconomic position and ethnicity.SSM - population health · 2022Article
- Skipping Breakfast and Incidence of Frequent Alcohol Drinking in University Students in Japan: A Retrospective Cohort Study.Nutrients · 2022Article
- Adolescent cocaine differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypes.Frontiers in psychiatry · 2022Article
- Co-occurring Mental Disorders in Transitional Aged Youth With Substance Use Disorders - A Narrative Review.Frontiers in psychiatry · 2022Review
- Common Liabilities in Internalizing Symptoms and Cigarette Use in Adolescence.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimsTo explore the developmental relationships between early-onset depressive disorders and later use of addictive substances. DESIGN, SETTING AND
participantsA sample of 1545 adolescent twins was drawn from a prospective, longitudinal study of Finnish adolescent twins with baseline assessments at age 14 years and follow-up at age 17.5 years. MEASUREMENTS: At baseline, DSM-IV diagnoses were assessed with a professionally administered adolescent version of Semi-Structured Assessment for Genetics of Alcoholism (C-SSAGA-A). At follow-up, substance use outcomes were assessed via self-reported questionnaire.
findingsEarly-onset depressive disorders predicted daily smoking [odds ratio (OR) 2.29, 95% confidence interval (CI) 1.49-3.50, P < 0.001], smokeless tobacco use (OR = 2.00, 95% CI 1.32-3.04, P = 0.001), frequent illicit drug use (OR = 4.71, 95% CI 1.95-11.37, P = 0.001), frequent alcohol use (OR = 2.02, 95% CI 1.04-3.92, P = 0.037) and recurrent intoxication (OR = 1.83, 95% CI 1.18-2.85, P = 0.007) 3 years later. ORs remained significant after adjustment for comorbidity and exclusion of baseline users. In within-family analysis of depression-discordant co-twins (analyses that control for shared genetic and familial background factors), early-onset depressive disorders at age 14 predicted significantly frequent use of smokeless tobacco and alcohol at age 17.5.
conclusionsOur results suggest important predictive associations between early-onset depressive disorders and addictive substance use, and these associations appear to be independent of shared familial influences.
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