ReviewAddiction biology2009
Identifying the neural circuitry of alcohol craving and relapse vulnerability.
Review in Addiction biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
138 citing papers in PubMed, 6 syntheses or guidelines pooled it, 313 citations in OpenAlex.
- What can case-control comparisons of neural drug cue reactivity tell us about addiction? A neuroimaging meta-analysis.Translational psychiatry · 2026Pooled it
- Functional magnetic response imaging predictors of alcohol use disorder treatment outcome: a systematic review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Pooled it
- Sociodemographic risk factors for the persistence of harmful alcohol use: a pooled analysis of prospective cohort studies.Social psychiatry and psychiatric epidemiology · 2025Pooled it
- An Overview of Appetite-Regulatory Peptides in Addiction Processes; From Bench to Bed Side.Frontiers in neuroscience · 2021Pooled it
- Imaging resilience and recovery in alcohol dependence.Addiction (Abingdon, England) · 2018Pooled it
- Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review.Addiction biology · 2013Pooled it
- Cue-exposure treatment influences resting-state functional connectivity-a randomized controlled fMRI study in alcohol use disorder.Psychopharmacology · 2024Trial
- Nalmefene attenuates neural alcohol cue-reactivity in the ventral striatum and subjective alcohol craving in patients with alcohol use disorder.Psychopharmacology · 2021Trial
- Baclofen attenuates fMRI alcohol cue reactivity in treatment-seeking alcohol dependent individuals.Psychopharmacology · 2021Trial
- Effects of cortisol administration on craving during in vivo exposure in patients with alcohol use disorder.Translational psychiatry · 2021Trial
- Neurofeedback Training versus Treatment-as-Usual for Alcohol Dependence: Results of an Early-Phase Randomized Controlled Trial and Neuroimaging Correlates.European addiction research · 2021Trial
- Effects of couple conflict on alcohol craving: Does intimate partner violence play a role?Addictive behaviors · 2020Trial
- The SyBil-AA real-time fMRI neurofeedback study: protocol of a single-blind randomized controlled trial in alcohol use disorder.BMC psychiatry · 2018Trial
- Adolescent heavy drinkers' amplified brain responses to alcohol cues decrease over one month of abstinence.Addictive behaviors · 2015Trial
- Intravenous ghrelin administration increases alcohol craving in alcohol-dependent heavy drinkers: a preliminary investigation.Biological psychiatry · 2014Trial
- Temptation to drink as a predictor of drinking outcomes following psychosocial treatment for alcohol dependence.Alcoholism, clinical and experimental research · 2013Trial
- Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment.Psychopharmacology · 2012Trial
- Reward-related brain response and craving correlates of marijuana cue exposure: a preliminary study in treatment-seeking marijuana-dependent subjects.Journal of addiction medicineTrial
- Psychosis in the Context of Travel, Substance Use, and Media Exposure: A Stress-Diathesis Perspective.Cureus · 2026Article
- Projection-specific roles of basolateral amygdala Thy1 neurons in alcohol-induced place preference.Molecular psychiatry · 2026Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
With no further intervention, relapse rates in detoxified alcoholics are high and usually exceed 80% of all detoxified patients. It has been suggested that stress and exposure to priming doses of alcohol and to alcohol-associated stimuli (cues) contribute to the relapse risk after detoxification. This article focuses on neuronal correlates of cue responses in detoxified alcoholics. Current brain imaging studies indicate that dysfunction of dopaminergic, glutamatergic and opioidergic neurotransmission in the brain reward system (ventral striatum including the nucleus accumbens) can be associated with alcohol craving and functional brain activation in neuronal systems that process attentional relevant stimuli, reward expectancy and experience. Increased functional brain activation elicited by such alcohol-associated cues predicted an increased relapse risk, whereas high brain activity elicited by affectively positive stimuli may represent a protective factor and was correlated with a decreased prospective relapse risk. These findings are discussed with respect to psychotherapeutic and pharmacological treatment options.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.