Evidence map›Paper›PMID 18855477›Full record

ArticleThe Journal of organic chemistry2008

Synthesis of P,N-heterocycles from omega-amino-H-phosphinates: conformationally restricted alpha-amino acid analogs.

Clémence Queffelec, Patrice Ribière, Jean-Luc Montchamp

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Phosphinate-containing heterocycles: A mini-review.Beilstein journal of organic chemistry · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Clémence QueffelecDepartment of Chemistry, Box 298860, Texas Christian University, Fort Worth, Texas 76129, USA.
Patrice Ribière
Jean-Luc Montchamp

Funding

H-Phosphinic Acids in the Preparation of Active Organophosphorus CompoundsR01GM067610 · NIGMS · TEXAS CHRISTIAN UNIVERSITY · PI MONTCHAMP, JEAN-LUC G · 2004 to 2008
$836k
NIGMS NIH HHS 1R01 GM067610NIGMS NIH HHS R01 GM067610
6 · The paper itself

Abstract

P,N-heterocycles (3-hydroxy-1,3-azaphospholane and 3-hydroxy-1,3-azaphosphorinane-3-oxide) are synthesized in moderate yield from readily available omega-amino-H-phosphinates and aldehydes or ketones via an intramolecular Kabachnik-Fields reaction. The products are conformationally restricted phosphinic analogs of alpha-amino acids. The multigram-scale syntheses of the H2N(CH2)(n)PO2H2 phosphinic precursors (n = 1, 2, 3) and some derivatives are also described.

Indexed as

Molecular ConformationAldehydesAmino AcidsAza CompoundsHeterocyclic CompoundsKetonesNitrogenPhosphinic AcidsPhosphorusAldehydesAmino AcidsAza CompoundsHeterocyclic CompoundsKetonesNitrogenPhosphinic AcidsPhosphorus

Identifiers

PMID18855477
PMCPMC2670240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.