ArticleMammalian genome : official journal of the International Mammalian Genome Society2008
Quantitative trait loci for porcine baseline erythroid traits at three growth ages in a White Duroc x Erhualian F(2) resource population.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
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- Genome-wide association studies for 30 haematological and blood clinical-biochemical traits in Large White pigs reveal genomic regions affecting intermediate phenotypes.Scientific reports · 2019Article
- Imputation-Based Whole-Genome Sequence Association Study Reveals Constant and Novel Loci for Hematological Traits in a Large-Scale Swine FFrontiers in genetics · 2018Article
- A systems genetics study of swine illustrates mechanisms underlying human phenotypic traits.BMC genomics · 2015Article
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- A comprehensive survey of copy number variation in 18 diverse pig populations and identification of candidate copy number variable genes associated with complex traits.BMC genomics · 2012Article
- Genetic analysis of hematological parameters in incipient lines of the collaborative cross.G3 (Bethesda, Md.) · 2012Article
- Genome-wide association study of porcine hematological parameters in a Large White × Minzhu F2 resource population.International journal of biological sciences · 2012Article
- Localization, expression change in PRRSV infection and association analysis of the porcine TAP1 gene.International journal of biological sciences · 2012Article
- Mapping quantitative trait loci for T lymphocyte subpopulations in peripheral blood in swine.BMC genetics · 2011Article
- Detection of quantitative trait loci affecting haematological traits in swine via genome scanning.BMC genetics · 2010Article
- The porcine ANG, RNASE1 and RNASE6 genes: molecular cloning, polymorphism detection and the association with haematological parameters.Molecular biology reports · 2009Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
Baseline erythroid indices are increasingly involved as risk factors for common complex diseases in humans. However, little is known about the genetic architecture of baseline erythroid traits in pigs. In this study, hematocrit (Hct), hemoglobin (Hgb), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), red blood cell (RBC), and red cell distribution width (RDW) were measured in 1420 (day 18), 1410 (day 46), and 1033 (day 240) F(2) pigs from a White Duroc x Erhualian intercross resource population. The entire resource population was genotyped for 183 microsatellite loci across the pig genome, and the quantitative trait loci (QTL) analysis was performed for all erythroid-related traits measured with QTL Express based on a least-squares method. A total of 101 QTL, including 46 genome-wide significant QTL and 55 chromosome-wide significant QTL, regulating erythroid traits were found on all pig chromosomes (SSC) except for SSC15 and SSC18. The genome-wide significant QTL were mainly localized on SSC1, 7, 8, 10, and X. These results confirmed most of QTL previously identified in the swine. More importantly, this study detected age-specific QTL for baseline erythroid traits in pigs for the first time. Notably, the QTL for MCV and MCH on day 18 on SSC8 with small intervals of 3 and 4 cM, respectively, provided a good starting point for identifying causal genes underlying MCV and MCH in the future.
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