ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2009
Practical limitations of bioresorbable membranes in the prevention of intra-abdominal adhesions.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Pooled it
- Trial
- Effect of Hydrogen-Rich Saline on Postoperative Intra-Abdominal Adhesion Bands Formation in Mice.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- A pectin-honey hydrogel prevents postoperative intraperitoneal adhesions in a rat model.BMC veterinary research · 2017Article
- Peritoneal adhesion prevention with a biodegradable and injectable N,O-carboxymethyl chitosan-aldehyde hyaluronic acid hydrogel in a rat repeated-injury model.Scientific reports · 2016Article
- Ghrelin ameliorates adhesions in a postsurgical mouse model.The Journal of surgical research · 2016Article
- In situ forming hydrogel composed of hyaluronate and polygalacturonic acid for prevention of peridural fibrosis.Journal of materials science. Materials in medicine · 2015Article
- Regulation of synthesis and roles of hyaluronan in peritoneal dialysis.BioMed research international · 2015Review
- PVA gel as a potential adhesion barrier: a safety study in a large animal model of intestinal surgery.Langenbeck's archives of surgery · 2014Article
- Article
- New hepatectomy-induced postoperative adhesion model in rats, and evaluation of the efficacy of anti-adhesion materials.Surgery today · 2014Article
- Trehalose does not affect the functions of human neutrophils in vitro.Surgery today · 2014Article
- Novel powdered anti-adhesion material: preventing postoperative intra-abdominal adhesions in a rat model.International journal of medical sciences · 2013Article
- Prevention of pleural adhesions by bioactive polypeptides - a pilot study.International journal of medical sciences · 2013Article
- Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies.Gynecological surgery · 2012Article
- Current strategies and future perspectives for intraperitoneal adhesion prevention.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Review
- A sprayable hyaluronate/carboxymethylcellulose adhesion barrier exhibits regional adhesion reduction efficacy and does not impair intestinal healing.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
- Pathophysiology and prevention of postoperative peritoneal adhesions.World journal of gastroenterology · 2011Review
- Evaluation of the xenobiotic reaction against hyaluronate-based bioresorbable membrane in the abdominal cavity.Progress in biomaterialsArticle
- Dual-sprayable, multi-functional hydrogel for effective prevention of peritoneal adhesions.Journal of tissue engineeringArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIntra-abdominal adhesions are a significant source of postoperative morbidity. Bioresorbable barriers composed of hyaluronic acid and carboxymethylcellulose (HA/CMC) reduce adhesion formation by physically separating injured or healing peritoneal surfaces. To assess whether the efficacy of a physical barrier can extend beyond the site of application, we evaluated the effectiveness of an HA/CMC barrier in preventing adhesions distal to the site of placement.
methodsAdhesions were induced in rats by creating peritoneal ischemic buttons on either side of a midline incision. An HA/CMC barrier (Seprafilm Genzyme) was intraoperatively placed either under the midline incision, unilaterally over half the ischemic buttons, or bilaterally over all ischemic buttons. Control buttons received no HA/CMC. On day 7 adhesions were scored. In similar experiments, peritoneal fluid was collected at 24 h to assess the effects of HA/CMC on tissue plasminogen activator activity.
resultsPlacement of HA/CMC under the midline incision did not reduce adhesion formation to distal ischemic buttons (72 +/- 7%) compared to controls (80 +/- 8%). Unilateral placement of HA/CMC significantly (p < 0.05) reduced adhesion formation to those ischemic buttons over which the barrier was applied (35 +/- 7%) compared to both contralateral (83 +/- 9%) and control (80 +/- 8%) ischemic buttons. The bilateral application of HA/CMC also significantly (p < 0.05) reduced adhesion formation to all ischemic buttons compared to controls (22 +/- 7% vs. 66 +/- 7%, respectively). HA/CMC did not affect peritoneal tPA activity.
conclusionsEffective adhesion reduction by the physical barrier HA/CMC appears to be limited to the site of application in this rat model. Despite the presence of a bioresorbable membrane at predicted sites of adhesion formation in the peritoneal cavity, adhesions readily form to distal unprotected sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.