ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2009
The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- Functions of secretory calcium-binding phosphoproteins in dental mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Review
- Comparison and Contrast of Bone and Dentin in Genetic Disorder, Morphology and Regeneration: A Review.Journal of bone metabolism · 2021Article
- Promoting Osseointegration of Dental Implants in Dog Maxillary Sinus Floor Augmentation Using Dentin Matrix Protein 1-Transduced Bone Marrow Stem Cells.Tissue engineering and regenerative medicine · 2020Article
- Probing the influence of SIBLING proteins on collagen-I fibrillogenesis and denaturation.Connective tissue research · 2018Article
- Cell-derived micro-environment helps dental pulp stem cells promote dental pulp regeneration.Cell proliferation · 2017Article
- Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization.Histochemistry and cell biology · 2017Article
- An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.European journal of histochemistry : EJH · 2015Article
- Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice.Human molecular genetics · 2014Article
- In vitro osteogenic/dentinogenic potential of an experimental calcium aluminosilicate cement.Journal of endodontics · 2013Article
- The dentin matrix acidic phosphoprotein 1 (DMP1) in the light of mammalian evolution.Journal of molecular evolution · 2013Article
- Immunohistochemical localization of the NH(2)-terminal and COOH-terminal fragments of dentin sialoprotein in mouse teeth.Cell and tissue research · 2012Article
- Effect of single-dose amoxicillin on rat incisor odontogenesis: a morphological study.Clinical oral investigations · 2012Article
- Protective roles of DMP1 in high phosphate homeostasis.PloS one · 2012Article
- Mineral abnormalities and long-term graft function in pediatric renal transplant recipients: a role for FGF-23?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2011Article
- Primary structure and phosphorylation of dentin matrix protein 1 (DMP1) and dentin phosphophoryn (DPP) uniquely determine their role in biomineralization.Biomacromolecules · 2011Article
- DMP1 processing is essential to dentin and jaw formation.Journal of dental research · 2011Article
- Possible role of DMP1 in dentin mineralization.Journal of structural biology · 2011Article
- The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis.Cells, tissues, organs · 2011Article
- The progressive ankylosis protein regulates cementum apposition and extracellular matrix composition.Cells, tissues, organs · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Multiple studies have shown that dentin matrix protein 1 (DMP1) is essential for bone and dentin mineralization. After post-translational proteolytic cleavage, DMP1 exists within the extracellular matrix of bone and dentin as an NH2-terminal fragment, a COOH-terminal fragment, and the proteoglycan form of the NH2-terminal fragment (DMP1-PG). To begin to assess the biological function of each fragment, we evaluated the distribution of both fragments in the rat tooth and bone using antibodies specific to the NH2-terminal and COOH-terminal regions of DMP1 and confocal microscopy. In rat first molar organs, the NH2-terminal fragment localized to predentin, whereas the COOH-terminal fragment was mainly restricted to mineralized dentin. In the growth plate of bone, the NH2-terminal fragment appeared in the proliferation and hypertrophic zones, whereas the COOH-terminal fragment occupied the ossification zone. Forster resonance energy transfer analysis showed colocalization of both fragments of DMP1 in odontoblasts and predentin, as well as hypertrophic chondrocytes within the growth plates of bone. The biochemical analysis of bovine teeth showed that predentin is rich in DMP1-PG, whereas mineralized dentin primarily contains the COOH-terminal fragment. We conclude that the differential patterns of expression of NH2-terminal and COOH-terminal fragments of DMP1 reflect their potentially distinct roles in the biomineralization of dentin and bone matrices.
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