ArticleGenetics2008
Regulation of Caenorhabditis elegans male mate searching behavior by the nuclear receptor DAF-12.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Neuropeptide signalling shapes feeding and reproductive behaviours in maleLife science alliance · 2022Article
- Cytochromes P450 ofBiomolecules · 2022Review
- Incomplete proline catabolism drives premature sperm aging.Aging cell · 2021Article
- Article
- Sexual Dimorphism and Sex Differences inGenetics · 2018Article
- Neural Circuitry That Mediates Behavior Governing the Tradeoffs Between Survival and Reproduction in Caenorhabditis elegans.Integrative and comparative biology · 2017Review
- Sexual modulation of sex-shared neurons and circuits in Caenorhabditis elegans.Journal of neuroscience research · 2017Review
- Influence of steroid hormone signaling on life span control by Caenorhabditis elegans insulin-like signaling.G3 (Bethesda, Md.) · 2013Article
- PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans.Nature neuroscience · 2012Article
- Sex differences in behavioral decision-making and the modulation of shared neural circuits.Biology of sex differences · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coordination of animal behavior with reproductive status is often achieved through elaboration of hormones by the gonad. In the nematode Caenorhabditis elegans, adult males explore their environment to locate mates. Mate searching is regulated by presence of mates, nutritional status, and a signal from the gonad. Here we show that the gonadal signal acts via the nuclear receptor DAF-12, a protein known to regulate several C. elegans life-history traits. DAF-12 has both activational and organizational functions to stimulate exploratory behavior and acts downstream of the gonadal signal, outside of the gonad. DAF-12 acts upstream of sensory input from mating partners and physiological signals indicating nutritional status. Mate searching was rescued in germ-line ablated animals, but not if both germ line and somatic gonad were ablated, by a precursor of the DAF-12 ligand, dafachronic acid (DA). The results are interpreted to suggest that the germ line produces a DA precursor that is converted to DA outside of the germ line, possibly in the somatic gonad. As it does in other pathways in which it functions, in regulation of male mate searching behavior DAF-12 acts at a choice point between alternatives favoring reproduction (mate searching) vs. survival (remaining on food).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.