ArticleGenetics2008
Genetics of mating and sex determination in the parasitic nematode Haemonchus contortus.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The Mitogenome of the Haecon-5 Strain ofInternational journal of molecular sciences · 2024Article
- Effect of Ivermectin on the Expression of P-Glycoprotein in Third-Stage Larvae ofAnimals : an open access journal from MDPI · 2023Article
- Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode.PLoS pathogens · 2022Article
- Selection of Genome-Wide SNPs for Pooled Allelotyping Assays Useful for Population Monitoring.Genome biology and evolution · 2022Article
- Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm.Communications biology · 2020Article
- Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis.PLoS neglected tropical diseases · 2020Article
- Small RNAs in parasitic nematodes - forms and functions.Parasitology · 2020Review
- Hidden in plain sight - Multiple resistant species within a strongyle community.Veterinary parasitology · 2018Article
- A Genome Resequencing-Based Genetic Map Reveals the Recombination Landscape of an Outbred Parasitic Nematode in the Presence of Polyploidy and Polyandry.Genome biology and evolution · 2018Article
- Population genomics of the filarial nematode parasite Wuchereria bancrofti from mosquitoes.Molecular ecology · 2016Article
- Inbreeding in stochastic subdivided mating systems: the genetic consequences of host spatial structure, aggregated transmission dynamics and life history characteristics in parasite populations.Journal of genetics · 2015Article
- Molecular epidemiology, phylogeny and evolution of the filarial nematode Wuchereria bancrofti.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Review
- Introgression of ivermectin resistance genes into a susceptible Haemonchus contortus strain by multiple backcrossing.PLoS pathogens · 2012Article
- WormBase: Annotating many nematode genomes.Worm · 2012Article
- Acquired immune heterogeneity and its sources in human helminth infection.Parasitology · 2011Review
- Anthelmintic resistance: markers for resistance, or susceptibility?Parasitology · 2011Review
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Genetic analysis of parasitic nematodes has been a neglected area of research and the basic genetics of this important group of pathogens are poorly understood. Haemonchus contortus is one of the most economically significant livestock parasites worldwide and is a key experimental model for the strongylid nematode group that includes many important human and animal pathogens. We have undertaken a study of the genetics and the mode of mating of this parasite using microsatellite markers. Inheritance studies with autosomal markers demonstrated obligate dioecious sexual reproduction and polyandrous mating that are reported here for the first time in a parasitic helminth and provide the parasite with a mechanism of increasing genetic diversity. The karyotype of the H. contortus, MHco3(ISE) isolate was determined as 2n = 11 or 12. We have developed a panel of microsatellite markers that are tightly linked on the X chromosome and have used them to determine the sex chromosomal karyotype as XO male and XX female. Haplotype analysis using the X-chromosomal markers also demonstrated polyandry, independent of the autosomal marker analysis, and enabled a more direct estimate of the number of male parental genotypes contributing to each brood. This work provides a basis for future forward genetic analysis on H. contortus and related parasitic nematodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.