ArticleGenetics2008
Surviving the bottleneck: transmission mutants and the evolution of microbial populations.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- A Selective Bottleneck During Host Entry Drives the Evolution of New Legume Symbionts.Molecular biology and evolution · 2023Article
- Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance.Nature ecology & evolution · 2021Article
- The roles of environmental variation and parasite survival in virulence-transmission relationships.Royal Society open science · 2021Review
- Article
- Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments.PLoS computational biology · 2020Article
- A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species.Science advances · 2019Article
- Article
- The impact of bottlenecks on microbial survival, adaptation, and phenotypic switching in host-pathogen interactions.Evolution; international journal of organic evolution · 2017Article
- Article
- Suppression of Beneficial Mutations in Dynamic Microbial Populations.Physical review letters · 2017Article
- Benefits of a Recombination-Proficient Escherichia coli System for Adaptive Laboratory Evolution.Applied and environmental microbiology · 2016Article
- Predation and selection for antibiotic resistance in natural environments.Evolutionary applications · 2016Article
- Article
- Crossing the scale from within-host infection dynamics to between-host transmission fitness: a discussion of current assumptions and knowledge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Article
- Payoffs, not tradeoffs, in the adaptation of a virus to ostensibly conflicting selective pressures.PLoS genetics · 2014Article
- Trade-offs between and within scales: environmental persistence and within-host fitness of avian influenza viruses.Proceedings. Biological sciences · 2014Article
- Modeling the potential impact of host population survival on the evolution of M. tuberculosis latency.PloS one · 2014Article
- Lotka-Volterra dynamics kills the Red Queen: population size fluctuations and associated stochasticity dramatically change host-parasite coevolution.BMC evolutionary biology · 2013Article
- Understanding barriers to Borrelia burgdorferi dissemination during infection using massively parallel sequencing.Infection and immunity · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The ability of microbial populations to increase fitness through fixation of mutants with an increased growth rate has been well described. In experimental studies, this is often the only way fitness can be increased. In natural settings, however, fitness can also be improved by increasing the ability of the microbe to transmit from one host to the next. For many pathogens, transmission includes a phase outside the host during which they need to survive before the chance of reinfecting a new host occurs. In such a situation, a reduced death rate during this phase will lead to improved fitness. Here, we compute the fixation probability of mutants that better survive the transmission bottleneck during the evolution of microbial populations. We derive analytical results that show that transmission mutants are often likely to occur and that their importance relative to growth mutants increases as the population decline during the transmission phase increases. We confirm our theoretical results with numerical simulations and suggest specific experiments that can be done to test our predictions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.