ArticleDevelopmental cell2008
Probing intrinsic properties of a robust morphogen gradient in Drosophila.
Article in Developmental cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- How nature discovers rare Turing islands: Exploration by common limit cycles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Rapid response of fly populations to gene dosage across development and generations.Nature communications · 2024Article
- Article
- Arp2/3-dependent mechanical control of morphogenetic robustness in an inherently challenging environment.Developmental cell · 2021Article
- Shadow enhancers can suppress input transcription factor noise through distinct regulatory logic.eLife · 2020Article
- Article
- Mechanisms and Measurements of Scale Invariance of Morphogen Gradients.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Article
- Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.Nature communications · 2015Article
- Morphogen rules: design principles of gradient-mediated embryo patterning.Development (Cambridge, England) · 2015Review
- Modulation of temporal dynamics of gene transcription by activator potency in the Drosophila embryo.Development (Cambridge, England) · 2015Article
- Probing the impact of temperature on molecular events in a developmental system.Scientific reports · 2015Article
- Intracellular Scaling Mechanisms.Cold Spring Harbor perspectives in biology · 2015Review
- Fundamental origins and limits for scaling a maternal morphogen gradient.Nature communications · 2015Article
- Robust and precise morphogen-mediated patterning: trade-offs, constraints and mechanisms.Journal of the Royal Society, Interface · 2015Article
- Shaped 3D singular spectrum analysis for quantifying gene expression, with application to the early zebrafish embryo.BioMed research international · 2015Article
- Mid-embryo patterning and precision in Drosophila segmentation: Krüppel dual regulation of hunchback.PloS one · 2015Article
- Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos.Development (Cambridge, England) · 2014Article
- Image analysis and empirical modeling of gene and protein expression.Methods (San Diego, Calif.) · 2013Article
- Uncovering a dynamic feature of the transcriptional regulatory network for anterior-posterior patterning in the Drosophila embryo.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A remarkable feature of development is its reproducibility, the ability to correct embryo-to-embryo variations and instruct precise patterning. In Drosophila, embryonic patterning along the anterior-posterior axis is controlled by the morphogen gradient Bicoid (Bcd). In this article, we describe quantitative studies of the native Bcd gradient and its target Hunchback (Hb). We show that the native Bcd gradient is highly reproducible and is itself scaled with embryo length. While a precise Bcd gradient is necessary for precise Hb expression, it still has positional errors greater than Hb expression. We describe analyses further probing mechanisms for Bcd gradient scaling and correction of its residual positional errors. Our results suggest a simple model of a robust Bcd gradient sufficient to achieve scaled and precise activation of its targets. The robustness of this gradient is conferred by its intrinsic properties of "self-correcting" the inevitable input variations to achieve a precise and reproducible output.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.