ArticleVirology journal2008
Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea.
Article in Virology journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 167 citations in OpenAlex.
- Comparison of classic and novel human astrovirus MLB and VA seroprevalence in HIV and non-HIV cohorts in South China demonstrates high seroreactivity to classic human astrovirus, which is associated with HIV infection.Microbiology spectrum · 2025Article
- Multi-epitope-based vaccine models prioritization against Astrovirus MLB1 using immunoinformatics and reverse vaccinology approaches.Journal, genetic engineering & biotechnology · 2025Article
- Mouse and human immune responses share neutralization epitopes of HAstV-VA1.Journal of virology · 2024Article
- Near-complete genome sequence of human astrovirus recovered from a child with acute flaccid paralysis in Guinea, 2021.Microbiology resource announcements · 2023Article
- Diversity of classic and novel human astrovirus in outpatient children with acute gastroenteritis in Shanghai, China.Frontiers in microbiology · 2023Article
- Gastrointestinal organoids in the study of viral infections.American journal of physiology. Gastrointestinal and liver physiology · 2023Review
- The Genomic and Genetic Evolution Analysis of Rabbit Astrovirus.Veterinary sciences · 2022Article
- Astrovirus-induced epithelial-mesenchymal transition via activated TGF-β increases viral replication.PLoS pathogens · 2022Article
- An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses.Viruses · 2022Review
- High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations.mSphere · 2021Article
- Hidden Viral Sequences in Public Sequencing Data and Warning for Future Emerging Diseases.mBio · 2021Article
- Human Astroviruses: A Tale of Two Strains.Viruses · 2021Article
- Isolation and Characterization of Porcine Astrovirus 5 from a Classical Swine Fever Virus-Infected Specimen.Journal of virology · 2020Article
- Analysis of viral diversity in stool samples from infants and children with acute gastroenteritis in Kuwait using Metagenomics approach.Virology journal · 2020Article
- Genetic Diversity of Astrovirus in Children From a Birth Cohort in Nepal.Frontiers in microbiology · 2020Article
- Astrovirus evolution and emergence.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2019Review
- Infection and Propagation of Astrovirus VA1 in Cell Culture.Current protocols in microbiology · 2019Article
- A decade of RNA virus metagenomics is (not) enough.Virus research · 2018Review
- Propagation of Astrovirus VA1, a Neurotropic Human Astrovirus, in Cell Culture.Journal of virology · 2017Article
- Case-Control Assessment of the Roles of Noroviruses, Human Bocaviruses 2, 3, and 4, and Novel Polyomaviruses and Astroviruses in Acute Childhood Diarrhea.Journal of the Pediatric Infectious Diseases Society · 2017Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAstroviruses infect a variety of mammals and birds and are causative agents of diarrhea in humans and other animal hosts. We have previously described the identification of several sequence fragments with limited sequence identity to known astroviruses in a stool specimen obtained from a child with acute diarrhea, suggesting that a novel virus was present.
resultsIn this study, the complete genome of this novel virus isolate was sequenced and analyzed. The overall genome organization of this virus paralleled that of known astroviruses, with 3 open reading frames identified. Phylogenetic analysis of the ORFs indicated that this virus is highly divergent from all previously described animal and human astroviruses. Molecular features that are highly conserved in human serotypes 1-8, such as a 3'NTR stem-loop structure and conserved nucleotide motifs present in the 5'NTR and ORF1b/2 junction, were either absent or only partially conserved in this novel virus.
conclusionBased on the analyses described herein, we propose that this newly discovered virus represents a novel species in the family Astroviridae. It has tentatively been named Astrovirus MLB1.
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