ArticleSleep2008
The non-benzodiazepine hypnotic zolpidem impairs sleep-dependent cortical plasticity.
Article in Sleep, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Traditional East Asian Herbal Medicine for Post-Stroke Insomnia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.International journal of environmental research and public health · 2022Pooled it
- The effect of two benzodiazepine receptor agonist hypnotics on sleep-dependent memory consolidation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Trial
- Slow wave sleep induced by GABA agonist tiagabine fails to benefit memory consolidation.Sleep · 2013Trial
- Review
- Acute and chronic zolpidem administration changes hippocampal long-term potentiation (LTP) as a possible mechanism of memory impairment.Iranian journal of basic medical sciences · 2026Article
- Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia.Communications biology · 2023Article
- Article
- Pharmacotherapeutic management of insomnia and effects on sleep processes, neural plasticity, and brain systems modulating stress: A narrative review.Frontiers in neuroscience · 2022Review
- Herbal medicine for post-stroke insomnia: A protocol for systematic review and meta-analysis.Medicine · 2021Article
- Challenging sleep homeostasis.Neurobiology of sleep and circadian rhythms · 2021Article
- The Engram's Dark Horse: How Interneurons Regulate State-Dependent Memory Processing and Plasticity.Frontiers in neural circuits · 2021Review
- Review
- Sleep-Wake Disorders in Stroke-Increased Stroke Risk and Deteriorated Recovery? An Evaluation on the Necessity for Prevention and Treatment.Current neurology and neuroscience reports · 2018Review
- Effect of zolpidem on functional recovery in a rat model of ischemic stroke.The Journal of international medical research · 2018Article
- Article
- Extracellular signal-regulated kinase (ERK) activity during sleep consolidates cortical plasticity in vivo.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Set and setting: how behavioral state regulates sensory function and plasticity.Neurobiology of learning and memory · 2013Review
- Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task.Psychopharmacology · 2013Article
- About sleep's role in memory.Physiological reviews · 2013Review
- Benzodiazepine oncogenesis as mediated via diminished restorative sleep effected sympathoadrenal activation.Mayo Clinic proceedings · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
STUDY
objectivesThe effects of hypnotics on sleep-dependent brain plasticity are unknown. We have shown that sleep enhances a canonical model of in vivo cortical plasticity, known as ocular dominance plasticity (ODP). We investigated the effects of 3 different classes of hypnotics on ODP.
designPolysomnographic recordings were performed during the entire experiment (20 h). After a baseline sleep/wake recording (6 h), cats received 6 h of monocular deprivation (MD) followed by an i.p. injection of triazolam (1-10 mg/kg i.p.), zolpidem (10 mg/kg i.p.), ramelteon (0.1-1 mg/kg i.p.), or vehicle (DMSO i.p.). They were then allowed to sleep ad lib for 8 h, after which they were prepared for optical imaging of intrinsic cortical signals and single-unit electrophysiology.
settingBasic neurophysiology laboratory PATIENTS OR
participantsCats (male and female) in the critical period of visual development (postnatal days 28-41)
interventionsN/A. MEASUREMENTS AND
resultsZolpidem reduced cortical plasticity by approximately 50% as assessed with optical imaging of intrinsic cortical signals. This was not due to abnormal sleep architecture because triazolam, which perturbed sleep architecture and sleep EEGs more profoundly than zolpidem, had no effect on plasticity. Ramelteon minimally altered sleep and had no effect on ODP.
conclusionsOur findings demonstrate that alterations in sleep architecture do not necessarily lead to impairments in sleep function. Conversely, hypnotics that produce more "physiological" sleep based on polysomnography may impair critical brain processes, depending on their pharmacology.
Indexed as
Identifiers
18853935PMC2572743W2150658436What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.