Evidence map›Paper›PMID 18853262›Full record

ArticleCancer causes & control : CCC2009

Cigarette smoking and the risk of Barrett's esophagus.

Ai Kubo, T R Levin, Gladys Block, Gregory Rumore, Charles P Quesenberry, Patricia Buffler, Douglas A Corley

Abstract read
In one paragraph

Article in Cancer causes & control : CCC, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Meta-analysis of Barrett's esophagus in China.World journal of gastroenterology · 2013
    Pooled it
  3. Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013
    Pooled it
  4. Article
  5. Article
  6. Global burden and epidemiology of Barrett oesophagus and oesophageal cancer.Nature reviews. Gastroenterology & hepatology · 2021
    Review
  7. The Y-chromosome F haplogroup contributes to the development of Barrett's esophagus-associated esophageal adenocarcinoma in a white male population.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2020
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. A review of the epidemiology of Barrett's oesophagus and oesophageal adenocarcinoma.Best practice & research. Clinical gastroenterology · 2015
    Review
  13. Role of chemoprophylaxis with either NSAIDs or statins in patients with Barrett's esophagus.World journal of gastrointestinal pharmacology and therapeutics · 2014
    Review
  14. Article
  15. Cigarette smoking is a modifiable risk factor for Barrett's oesophagus.United European gastroenterology journal · 2013
    Article
  16. Age at onset of GERD symptoms predicts risk of Barrett's esophagus.The American journal of gastroenterology · 2013
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ai KuboDivision of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA. ai.kubo@kp.org
T R Levin
Gladys Block
Gregory Rumore
Charles P Quesenberry
Patricia Buffler
Douglas A Corley
Kaiser Permanente · USUniversity of California System · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Epidemiology and Incidence of Barrett's EsophagusR01DK063616 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI CORLEY, DOUGLAS ALLEN · 2002 to 2010
$2.6M
ETIOLOGIES/SURVEILLANCE OF BARRETT'S ESOPHAGUSK08DK002697 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CORLEY, DOUGLAS ALLEN · 2000 to 2004
$599k
The effects of Diet on Barrett's esophagus and gastroesophageal reflux diseaseF32DK081271 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI KUBO, AI · 2008 to 2009
$92k
NIDDK NIH HHS F32 DK081271NIDDK NIH HHS K08 DK 002697NIDDK NIH HHS K08 DK002697NIDDK NIH HHS R01 DK063616NIDDK NIH HHS R01 DK 63616
6 · The paper itself

Abstract

introductionWe examined the association between smoking and the risk of Barrett's esophagus (BE), a metaplastic precursor to esophageal adenocarcinoma.

methodsWe conducted a case-control study within the Kaiser Permanente Northern California population. Patients with a new diagnosis of BE (n = 320) were matched to persons with gastroesophageal reflux disease (GERD) (n = 316) and to population controls (n = 317). Information was collected using validated questionnaires from direct in-person interviews and electronic databases. Analyses used multivariate unconditional logistic regression that controlled for age, gender, race, and education.

resultsEver smoking status, smoking intensity (pack-years), and smoking cessation were not associated with the risk of BE. Stratified analyses suggested that ever smoking may be associated with an increased risk of BE among some groups (compared to population controls): persons with long-segment Barrett's esophagus (odds ratio [OR] = 1.72, 95% confidence interval [CI] 1.12-2.63); subjects without GERD symptoms (OR = 3.98, 95% CI 1.58-10.0); obese subjects (OR = 3.38, 95% CI 1.46-7.82); and persons with a large abdominal circumference (OR = 3.02, 95% CI (1.18-2.75)).

conclusionSmoking was not a strong or consistent risk factor for BE in a large community-based study, although associations may be present in some population subgroups.

Indexed as

AdenocarcinomaAdolescentAdultAgedAlcohol DrinkingBarrett EsophagusBody Mass IndexCaliforniaCase-Control StudiesConfidence IntervalsConfounding Factors, EpidemiologicDatabases, FactualEsophageal NeoplasmsGastroesophageal RefluxGeographyHumans

Identifiers

PMID18853262
PMCPMC2649684
OpenAlexW2052071687

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.