ArticleGlycoconjugate journal2009
Analysis of N-glycans in embryonated chicken egg chorioallantoic and amniotic cells responsible for binding and adaptation of human and avian influenza viruses.
Article in Glycoconjugate journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Targeting virus-glycan recognition in influenza viruses and coronaviruses: from the molecular principles to glycomimetic antivirals strategies.RSC chemical biology · 2026Review
- Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site.Cell host & microbe · 2024Article
- Glycoblotting-Based Ovo-Sulphoglycomics Reveals PhosphorylatedACS infectious diseases · 2024Article
- MAIVeSS: streamlined selection of antigenically matched, high-yield viruses for seasonal influenza vaccine production.Nature communications · 2024Article
- Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines.Nature communications · 2023Article
- Roles of Glycans and Non-glycans on the Epithelium and in the Immune System in H1-H18 Influenza A Virus Infections.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Enhanced isolation of influenza viruses in qualified cells improves the probability of well-matched vaccines.NPJ vaccines · 2021Article
- Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans.The Journal of clinical investigation · 2021Article
- Influenza Hemagglutinin Structures and Antibody Recognition.Cold Spring Harbor perspectives in medicine · 2020Review
- Quadrivalent cell culture influenza virus vaccine. Comparison to egg-derived vaccine.Human vaccines & immunotherapeutics · 2020Article
- Sialoglycovirology of Lectins: Sialyl Glycan Binding of Enveloped and Non-enveloped Viruses.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility.Cell host & microbe · 2019Article
- A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.PLoS pathogens · 2017Article
- Site-specific glycosylation of the Newcastle disease virus haemagglutinin-neuraminidase.Glycoconjugate journal · 2017Article
- Cellular scent of influenza virus infection.Chembiochem : a European journal of chemical biology · 2014Article
- Molecular basis of a pandemic of avian-type influenza virus.Methods in molecular biology (Clifton, N.J.) · 2014Review
- H5N1 receptor specificity as a factor in pandemic risk.Virus research · 2013Review
- Cytotoxicity and glycan-binding properties of an 18 kDa lectin isolated from the marine sponge Halichondria okadai.Toxins · 2012Article
- Molecular basis of the structure and function of H1 hemagglutinin of influenza virus.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2012Review
- Binding of avian coronavirus spike proteins to host factors reflects virus tropism and pathogenicity.Journal of virology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The initial step essential in influenza virus infection is specific binding of viral hemagglutinin to host cell-surface glycan receptors. Influenza A virus specificity for the host is mediated by viral envelope hemagglutinin, that binds to receptors containing glycans with terminal sialic acids. Human viruses preferentially bind to alpha2-->6 linked sialic acids on receptors of host cells, whereas avian viruses are specific for the alpha2-->3 linkage on the target cells. Human influenza virus isolates more efficiently infect amniotic membrane (AM) cells than chorioallantoic membrane (CAM) cells. N-glycans were isolated from AM and CAM cells of 10-day-old chicken embryonated eggs and their structures were analyzed by multi-dimensional HPLC mapping and MALDI-TOF-MS techniques. Terminal N-acetylneuraminic acid contents in the two cell types were similar. However, molar percents of alpha2-->3 linkage preferentially bound by avian influenza virus were 27.2 in CAM cells and 15.4 in AM cells, whereas those of alpha2-->6 linkage favored by human influenza virus were 8.3 (CAM) and 14.2 (AM). Molar percents of sulfated glycans, recognized by human influenza virus, in CAM and AM cells were 3.8 and 12.7, respectively. These results have revealed structures and molar percents of N-glycans in CAM and AM cells important in determining human and avian influenza virus infection and viral adaptation.
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