ArticleBrazilian journal of otorhinolaryngology
Laryngeal papillomatosis: morphological study by light and electron microscopy of the HPV-6.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Tracing human papillomavirus in skin and mucosal squamous cell carcinoma: a histopathological retrospective survey.Dermatology reports · 2024Article
- Histopathological Study of Benign Tumours of the Larynx: A Descriptive Study in Coastal Karnataka.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Laryngeal verruca vulgaris.BMJ case reports · 2015Article
- Koilocytes indicate a role for human papilloma virus in breast cancer.British journal of cancer · 2009Article
- Role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review.Head & neck oncology · 2009Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledLaryngeal papillomatosis is the most frequent benign neoplasia in children. It is caused by HPV 6 and 11. The lesions are exophytic and highly recurrent, compromising the airway mucosa, mainly the larynx. Study design--clinical prospective.
aimsTo show morphologic alterations of the epithelium (light and electron microscopy) in the HPV-6 lesions.
methodsSpecimens of laryngeal lesions obtained during surgery of four children (1 male, 3 female) were submitted to HPV typing (PCR), light microscopy and electron microscopy.
resultsIn all specimens, HPV type 6 was found. Epithelial projections were found by electron microscopy with superficial cells in desquamation. Light microscopy showed exophytic projections of the keratinized stratified squamous epithelium overlying a fibrovascular core. Koilocytes (vacuolated cells), suggesting the viral infection by HPV, were identified. No alterations were seen in the basement membrane and corion. Ultraestrutural analysis showed vacuolated cells with clear cytoplasmic inclusions, intercellular injuries and widening intercellular spaces.
conclusionsmorphologic alterations of the epithelium in the HPV-6 lesions are superficial, and additional studies including the others HPV types are needed to show the more aggressive and extensive aspect of the disease.
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