ArticleProceedings of the National Academy of Sciences of the United States of America2008
Global gene expression profiles for life stages of the deadly amphibian pathogen Batrachochytrium dendrobatidis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 109 citations in OpenAlex.
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- Single-cell genomics, metagenomics, and transcriptomics ofAquatic ecology · 2026Article
- Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi.Molecular biology of the cell · 2025Article
- Gene Expression in Aphelid Zoospores Reveals Their Transcriptional and Translational Activity and Alacrity for Invasion.Journal of fungi (Basel, Switzerland) · 2025Article
- Mycoparasites, Gut Dwellers, and Saprotrophs: Phylogenomic Reconstructions and Comparative Analyses of Kickxellomycotina Fungi.Genome biology and evolution · 2023Article
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- Epidermal galactose spurs chytrid virulence and predicts amphibian colonization.Nature communications · 2021Article
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- Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections.Life (Basel, Switzerland) · 2020Review
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- Reference gene screening of Batrachochytrium dendrobatidis and Batrachochytrium salamandrivorans for quantitative real-time PCR studies.Scientific reports · 2019Article
- Leveraging single-cell genomics to expand the fungal tree of life.Nature microbiology · 2018Article
- Low resistance to chytridiomycosis in direct-developing amphibians.Scientific reports · 2017Article
- Fungal lifestyle reflected in serine protease repertoire.Scientific reports · 2017Article
- Characterization ofFrontiers in microbiology · 2017Article
- Contribution of Multiple Inter-Kingdom Horizontal Gene Transfers to Evolution and Adaptation of Amphibian-Killing Chytrid, Batrachochytrium dendrobatidis.Frontiers in microbiology · 2016Article
- Amphibian chytridiomycosis: a review with focus on fungus-host interactions.Veterinary research · 2015Review
- Article
- Quantitative Proteomics of an Amphibian Pathogen, Batrachochytrium dendrobatidis, following Exposure to Thyroid Hormone.PloS one · 2015Article
- Compositions of fungal secretomes indicate a greater impact of phylogenetic history than lifestyle adaptation.BMC genomics · 2014Article
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4 authors at 4 institutions in 3 countries.
Funding
Abstract
Amphibians around the world are being threatened by an emerging pathogen, the chytrid fungus Batrachochytrium dendrobatidis (Bd). Despite intensive ecological study in the decade since Bd was discovered, little is known about the mechanism by which Bd kills frogs. Here, we compare patterns of global gene expression in controlled laboratory conditions for the two phases of the life cycle of Bd: the free-living zoospore and the substrate-embedded sporangia. We find zoospores to be transcriptionally less complex than sporangia. Several transcripts more abundant in zoospores provide clues about how this motile life stage interacts with its environment. Genes with higher levels of expression in sporangia provide new hypotheses about the molecular pathways involved in metabolic activity, flagellar function, and pathogenicity in Bd. We highlight expression patterns for a group of fungalysin metallopeptidase genes, a gene family thought to be involved in pathogenicity in another group of fungal pathogens that similarly cause cutaneous infection of vertebrates. Finally we discuss the challenges inherent in developing a molecular toolkit for chytrids, a basal fungal lineage separated by vast phylogenetic distance from other well characterized fungi.
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