ArticleProceedings of the National Academy of Sciences of the United States of America2008
Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Microduplications disrupting the MYT1L gene (2p25.3) are associated with schizophrenia.Psychiatric genetics · 2012Pooled it
- Time-lapse mapping of cortical changes in schizophrenia with different treatments.Cerebral cortex (New York, N.Y. : 1991) · 2009Trial
- Schizophrenia: from mechanism to therapy.Science China. Life sciences · 2026Review
- Anatomy-aware, label-informed approach improves image registration for challenging datasets.PloS one · 2026Article
- Autistic Traits in Schizophrenia: Immune Mechanisms and Inflammatory Biomarkers.International journal of molecular sciences · 2025Review
- Impact of second-generation antipsychotics monotherapy or combined therapy in cytokine, lymphocyte subtype, and thyroid antibodies for schizophrenia: a retrospective study.BMC psychiatry · 2024Article
- Shared patterns of glial transcriptional dysregulation link Huntington's disease and schizophrenia.Brain : a journal of neurology · 2024Article
- A longitudinal resource for studying connectome development and its psychiatric associations during childhood.Scientific data · 2022Article
- Distinct influence of parental occupation on cortical thickness and surface area in children and adolescents: Relation to self-esteem.Human brain mapping · 2020Article
- Differential White Matter Maturation from Birth to 8 Years of Age.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Maturational Changes in Human Dorsal and Ventral Visual Networks.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Inflammation in Schizophrenia: Pathogenetic Aspects and Therapeutic Considerations.Schizophrenia bulletin · 2018Review
- Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.Cell stem cell · 2017Article
- Modular-level alterations of structure-function coupling in schizophrenia connectome.Human brain mapping · 2017Article
- Biomechanical Analysis of Normal Brain Development during the First Year of Life Using Finite Strain Theory.Scientific reports · 2016Article
- Putamen Development in Children 12 to 21 Months Old.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
- Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings.Schizophrenia research · 2016Review
- Autism As a Disorder of High Intelligence.Frontiers in neuroscience · 2016Article
- Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials.Mediators of inflammation · 2016Review
- Local-to-remote cortical connectivity in early- and adulthood-onset schizophrenia.Translational psychiatry · 2015Article
9 more citing papers are in PubMed but not listed here.
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11 authors at 1 institution in 1 country.
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Abstract
Earlier studies revealed progressive cortical gray matter (GM) loss in childhood-onset schizophrenia (COS) across both lateral and medial surfaces of the developing brain. Here, we use tensor-based morphometry to visualize white matter (WM) growth abnormalities in COS throughout the brain. Using high-dimensional elastic image registration, we compared 3D maps of local WM growth rates in COS patients and healthy children over a 5-year period, based on analyzing longitudinal brain MRIs from 12 COS patients and 12 healthy controls matched for age, gender, and scan interval. COS patients showed up to 2.2% slower growth rates per year than healthy controls in WM (P = 0.02, all P values corrected). The greatest differences were in the right hemisphere (P = 0.006). This asymmetry was attributable to a right slower than left hemisphere growth rate mapped in COS patients (P = 0.037) but not in healthy controls. WM growth rates reached 2.6% per year in healthy controls (P = 0.0002). COS patients showed only a 1.3% per year trend for growth in the left hemisphere (P = 0.066). In COS, WM growth rates were associated with improvement in the Children's Global Assessment Scale (R = 0.64, P = 0.029). Growth rates were reduced throughout the brain in COS, but this process appeared to progress in a front-to-back (frontal-parietal) fashion, and this effect was not attributable to lower IQ. Growth rates were correlated with functional prognosis and were visualized as detailed 3D maps. Finally, these findings also confirm that the progressive GM deficits seen in schizophrenia are not the result of WM overgrowth.
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