Trial reportDiabetes2009
Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans.
Trial report in Diabetes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04305093 (Precision Analytical Retrospective Data Correlation), which is not on this map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precision Analytical Retrospective Data Correlation
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Thyroid function spectrum in Cushing's syndrome.BMC endocrine disorders · 2024Pooled it
- Safety, tolerability, pharmacodynamics and pharmacokinetics following once-daily doses of BI 187004, an inhibitor of 11 beta-hydroxysteroid dehydrogenase-1, over 28 days in patients with type 2 diabetes mellitus and overweight or obesity.Diabetes, obesity & metabolism · 2023Trial
- Selective Inhibition of 11beta-Hydroxysteroiddehydrogenase-1 with BI 187004 in Patients with Type 2 Diabetes and Overweight or Obesity: Safety, Pharmacokinetics, and Pharmacodynamics After Multiple Dosing Over 14 Days.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2022Trial
- Effects of Obesity and Insulin on Tissue-Specific Recycling Between Cortisol and Cortisone in Men.The Journal of clinical endocrinology and metabolism · 2021Trial
- Diet-induced weight loss alters hepatic glucocorticoid metabolism in type 2 diabetes mellitus.European journal of endocrinology · 2020Trial
- A Short Study Exploring the Effect of the Glycaemic Index of the Diet on Energy intake and Salivary Steroid Hormones.Nutrients · 2019Trial
- Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus.The Journal of clinical endocrinology and metabolism · 2016Trial
- Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation.Cell metabolism · 2016Trial
- Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women.International journal of obesity (2005) · 2015Trial
- Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist.The Journal of clinical endocrinology and metabolism · 2014Trial
- The postprandial rise in plasma cortisol in men is mediated by macronutrient-specific stimulation of adrenal and extra-adrenal cortisol production.The Journal of clinical endocrinology and metabolism · 2014Trial
- Reduced cortisol metabolism during critical illness.The New England journal of medicine · 2013Trial
- Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization.Diabetes · 2012Trial
- Glucocorticoids turn over slowly in human adipose tissue in vivo.The Journal of clinical endocrinology and metabolism · 2010Trial
- Determination of hydrocortisone and cortisone in artificial saliva by spray assisted fine droplet formation liquid phase microextraction coupled to LC-MS/MS.Scientific reports · 2026Article
- Adipokine, endocrine, and fibrinolysis-related alterations across abdominal obesity and metabolic syndrome phenotypes in young adults.Frontiers in endocrinology · 2026Article
- Relationship of body composition with cortisol and dehydroepiandrosterone sulfate levels in Korean men and women.The Journal of international medical research · 2026Article
- Clinical Thresholds for Visceral Adiposity Accumulation: A Comparative Analysis in Sex-, Age-, and BMI-Matched Black and White Adults.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Genome-wide association and fine-mapping analyses identify novel candidate genes affecting serum cortisol levels using imputed whole-genome sequencing data in pigs.Journal of animal science and technology · 2025Article
- Cortisol, DHEA-S, and cortisol/DHEA-S ratio in association with oxidative stress in Korean adults.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objective11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) regenerates cortisol from cortisone. 11beta-HSD1 mRNA and activity are increased in vitro in subcutaneous adipose tissue from obese patients. Inhibition of 11beta-HSD1 is a promising therapeutic approach in type 2 diabetes. However, release of cortisol by 11beta-HSD1 from adipose tissue and its effect on portal vein cortisol concentrations have not been quantified in vivo. RESEARCH DESIGN AND
methodsSix healthy men underwent 9,11,12,12-[(2)H](4)-cortisol infusions with simultaneous sampling of arterialized and superficial epigastric vein blood sampling. Four men with stable chronic liver disease and a transjugular intrahepatic porto-systemic shunt in situ underwent tracer infusion with simultaneous sampling from the portal vein, hepatic vein, and an arterialized peripheral vein.
resultsSignificant cortisol and 9,12,12-[(2)H](3)-cortisol release were observed from subcutaneous adipose tissue (15.0 [95% CI 0.4-29.5] and 8.7 [0.2-17.2] pmol . min(-1) . 100 g(-1) adipose tissue, respectively). Splanchnic release of cortisol and 9,12,12-[(2)H](3)-cortisol (13.5 [3.6-23.5] and 8.0 [2.6-13.5] nmol/min, respectively) was accounted for entirely by the liver; release of cortisol from visceral tissues into portal vein was not detected.
conclusionsCortisol is released from subcutaneous adipose tissue by 11beta-HSD1 in humans, and increased enzyme expression in obesity is likely to increase local glucocorticoid signaling and contribute to whole-body cortisol regeneration. However, visceral adipose 11beta-HSD1 activity is insufficient to increase portal vein cortisol concentrations and hence to influence intrahepatic glucocorticoid signaling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.